2023 World Conference on Lung Cancer (Posters)-EP03.03. Multi-omics Analysis of Immune Determinants of STK11 in Non-Small Cell Lung Cancer

EP03.03. Multi-omics Analysis of Immune Determinants of STK11 in Non-Small Cell Lung Cancer - PDF(Slides)

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The study examined the impact of mutations in the STK11 gene on the immune microenvironment of non-small cell lung cancer (NSCLC) through multi-omics analyses. The researchers used data from The Cancer Genomic Atlas (TCGA) pan cancer lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) cohorts. They found that STK11 mutations were more common in LUAD patients compared to LUSC patients. The most common mutations observed in STK11-mutated tumors were in the KRAS and KEAP1 genes.<br /><br />The study also looked at the association between STK11 mutations and immune cell infiltration in the tumor. They found that STK11-mutated tumors had lower levels of CD8 T-cells and CD4 T-cells, higher levels of T-regulatory cells, and higher levels of M1 macrophages compared to STK11 wild-type tumors.<br /><br />Furthermore, the researchers assessed the correlation between STK11 mutations and cytotoxic T-lymphocytes (CTL) dysfunction using the Tumor Immune Dysfunction and Exclusion (TIDE) platform. They found that STK11 mutations were associated with CTL dysfunction.<br /><br />The findings of this study suggest that STK11 mutations are associated with a "cold" immune microenvironment in NSCLC, characterized by high levels of immune-inhibitory cells and low levels of immune-stimulatory cells. This may explain why patients with STK11 mutations have poorer outcomes and are less likely to respond to immunotherapy.<br /><br />In summary, this study provides insights into the immune determinants of STK11 in NSCLC. The findings suggest that STK11 mutations are associated with an immune-suppressive tumor microenvironment and CTL dysfunction, which may contribute to poor response to immunotherapy.

Asset Subtitle

Sanad Alhushki

Meta Tag

Speaker Sanad Alhushki

Topic Tumor Biology: Translational Biology - IO

Keywords

STK11 gene

mutations

immune microenvironment

NSCLC

LUAD

LUSC

KRAS gene

CD8 T-cells

CTL dysfunction

immunotherapy