2023 World Conference on Lung Cancer (Posters)-EP03.05. Genomic Landscape Features of Minimally Invasive Adenocarcinoma and Invasive Lung Adenocarcinoma

EP03.05. Genomic Landscape Features of Minimally Invasive Adenocarcinoma and Invasive Lung Adenocarcinoma - PDF(Abstract)

Back to course

Pdf Summary

This study aimed to investigate the genomic features of minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) in lung cancer patients. Using next generation sequencing, genetic data from a total of 422 tumor tissue samples were analyzed. MIA patients were predominantly female and younger compared to IAC patients. High frequency mutations in MIA included EGFR, ERBB2, KRAS, BRAF, MET, TP53, BRAC2, RET, and PIK3CA, while high frequency mutations in IAC included EGFR, TP53, KRAS, PIK3CA, CDKN2A, ERBB2, and CDK4. Significantly more genomic mutations in ERBB2 and BRAF, and significantly fewer mutations in EGFR, TP53, and CDKN2A were observed in MIA compared to IAC patients. Gene fusions, specifically RET fusions, were also identified in a small percentage of MIA and IAC patients. Interestingly, germline variants were found in IAC patients but were undetectable in MIA patients. The study concludes that mutations in ERBB2, BRAF, and RET fusion are early genomic events in the development of lung adenocarcinoma, while TP53, CDKN2A, and metastasis-related genes may be late events. The presence of genomic intratumor heterogeneity suggests that it may occur before the acquisition of invasion.

Asset Subtitle

Bo Liu

Meta Tag

Speaker Bo Liu

Topic Tumor Biology: Translational Biology - Omics and New Technologies

Keywords

genomic features

minimally invasive adenocarcinoma

invasive adenocarcinoma

lung cancer patients

next generation sequencing

EGFR

ERBB2

KRAS

BRAF

MET