2023 World Conference on Lung Cancer (Posters)-EP03.05. Hollow-MnO2 Nanofabricated Platform Equipped with Carbon Monoxide Gas Combined with SDT Enhanced ROS Generator for Lung Cancer Treatment

EP03.05. Hollow-MnO2 Nanofabricated Platform Equipped with Carbon Monoxide Gas Combined with SDT Enhanced ROS Generator for Lung Cancer Treatment - PDF(Abstract)

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This study focuses on the development of a nanotherapy system for the treatment of lung cancer using a combination of carbon monoxide (CO) gas and Sonodynamic therapy (SDT). The researchers utilized hollow structure manganese dioxide nanoparticles as a carrier, loaded with a sound sensitizer and CO donor, to create a tumor nanotherapy system based on a reactive oxygen species (ROS) cascade. <br /><br />ROS has been found to play a crucial role in antitumor therapy by stimulating oxidative damage in cancer cells and inducing apoptosis. Meanwhile, CO has desirable antitumor effects by directly inducing apoptosis in cancer cells. <br /><br />The researchers demonstrated that the combination of CO and SDT can be achieved by releasing CO in the ROS cascade response. SDT produces ROS at the tumor site to kill tumor cells, while also acting as a controlled release stimulus for CO. This cascade response helps avoid CO damage to normal tissues and improves the therapeutic effect of SDT. Additionally, CO increases the sensitivity of tumors to ROS, further amplifying the therapeutic effect of SDT.<br /><br />The study concludes that the developed nanoscale system is highly safe, exhibits excellent therapeutic effects, and can suppress tumor recurrence and metastasis to some extent. This research has significant value and importance in realizing the synergistic therapeutic effect of CO and SDT in the clinical treatment of lung cancer.

Asset Subtitle

Yujia fang

Meta Tag

Speaker Yujia fang

Topic Tumor Biology: Translational Biology - Omics and New Technologies

Keywords

nanotherapy system

lung cancer

carbon monoxide

Sonodynamic therapy

manganese dioxide nanoparticles

reactive oxygen species

apoptosis

antitumor therapy

controlled release stimulus

tumor recurrence