2023 World Conference on Lung Cancer (Posters)-EP03.05. Hollow-MnO2 Nanofabricated Platform Equipped with Carbon Monoxide Gas Combined with SDT Enhanced ROS Generator for Lung Cancer Treatment

EP03.05. Hollow-MnO2 Nanofabricated Platform Equipped with Carbon Monoxide Gas Combined with SDT Enhanced ROS Generator for Lung Cancer Treatment - PDF(Slides)

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Researchers from the Department of Medical Oncology at Shanghai Pulmonary Hospital have developed a strategy to fight lung cancer using endogenous and exogenous stimuli-triggered cascade catalysis. The team constructed a compound called MnCO/Ce6@H-MnO2, which aims to elevate the level of reactive oxygen species (ROS) and produce long-lived carbon monoxide (CO) in order to combat lung cancer.<br /><br />The strategy involves using intratumoral hydrogen peroxide (H2O2) and ultrasound as the endogenous and exogenous triggers respectively. These triggers stimulate H-MnO2 and Ce6, components of the MnCO/Ce6@H-MnO2 compound, to produce hydroxyl radicals (•OH) and singlet oxygen (^1O2), which in turn elevate the ROS level in the tumor.<br /><br />Furthermore, the researchers found that the cascade reaction between the ROS and Mn2(CO)10, another component of the compound, can release CO. This switch from short-lived ROS to long-lived CO is crucial in the fight against lung cancer.<br /><br />The researchers evaluated the efficacy of their strategy through in vivo anticancer therapy experiments. By combining the maximum accumulation of ROS with the release of long-lived CO, they demonstrated the potential of this approach in treating lung cancer.<br /><br />Overall, the research highlights the importance of endogenous and exogenous stimuli-triggered cascade catalysis in fighting lung cancer. By developing a compound that can elevate ROS levels and release long-lived CO, the researchers have identified a promising therapeutic strategy. This approach could potentially lead to new and more effective treatments for lung cancer patients.

Asset Subtitle

Yujia fang

Meta Tag

Speaker Yujia fang

Topic Tumor Biology: Translational Biology - Omics and New Technologies

Keywords

Shanghai Pulmonary Hospital

lung cancer

cascade catalysis

MnCO/Ce6@H-MnO2

reactive oxygen species

carbon monoxide

hydrogen peroxide

ultrasound

in vivo therapy

therapeutic strategy