2023 World Conference on Lung Cancer (Posters)-EP03.05. RNA Sequencing to Characterize Pathways in Patients with EGFR-mutated Non-Small Cell Lung Cancer

EP03.05. RNA Sequencing to Characterize Pathways in Patients with EGFR-mutated Non-Small Cell Lung Cancer - PDF(Abstract)

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This study aimed to assess the differences in gene expression pathways in patients with EGFR-mutated non-small cell lung cancer (NSCLC) based on age. A total of 281 patients were identified and a differential gene expression analysis was performed using comprehensive RNA sequencing data. The analysis focused on patients who were either above or below 70 years old at diagnosis. <br /><br />The results revealed significant differences in gene expression between the two age groups. Specifically, patients above 70 years old showed up-regulation of cortisol and aldosterone synthesis and secretion, as well as processes related to Cushing’s syndrome. Additionally, down-regulation of lipid mobilization and carbohydrate metabolism was observed. No disruptions were found in the primary circadian pathway despite the association with cortisol secretion and Cushing’s disease. <br /><br />Overall, the study demonstrated that age plays a role in the gene expression profiles of EGFR-mutated NSCLC patients. Up-regulated pathways related to cancer cachexia and inflammation were observed in patients above 70 years old at diagnosis. The use of RNA sequencing proved to be a promising tool in translating genomic features into clinical characteristics in EGFR-mutated lung cancer patients.

Asset Subtitle

Nicole Yun

Meta Tag

Speaker Nicole Yun

Topic Tumor Biology: Translational Biology - Omics and New Technologies

Keywords

gene expression pathways

EGFR-mutated non-small cell lung cancer

age

differential gene expression analysis

RNA sequencing data

patients

70 years old

cortisol

aldosterone synthesis

Cushing's syndrome