2023 World Conference on Lung Cancer (Posters)-EP04.01. METTL7A Inhibits Cell Proliferation and M2-Like Polarisation of Tumor-Associated Macrophage in Lung Adenocarcinoma

EP04.01. METTL7A Inhibits Cell Proliferation and M2-Like Polarisation of Tumor-Associated Macrophage in Lung Adenocarcinoma - PDF(Abstract)

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In this study, researchers aimed to investigate the role and prognostic value of the METTL7A protein in the development and progression of lung adenocarcinoma (LUAD), as well as its impact on tumor immunity. They analyzed METTL7A expression patterns in clinical samples and public tumor databases, and conducted various experiments to verify its function in LUAD.<br /><br />The results showed that METTL7A expression in LUAD tissues was lower compared to neighboring non-tumor lung tissues. Low METTL7A expression was also associated with adverse overall survival and negatively correlated with LUAD grade and stage. Furthermore, METTL7A expression was negatively correlated with promoter methylation.<br /><br />The researchers also identified positively and negatively correlated genes with METTL7A using the LinkedOmics database. Gene ontology and pathway analysis revealed that METTL7A potentially contributes to immune response regulation signaling pathways and T cell activation, while negatively affecting spliceosomes and cell cycle pathways.<br /><br />In vitro experiments demonstrated that METTL7A overexpression inhibited cell proliferation and migration, as well as M2 polarization of tumor-associated macrophages (TAMs). Cox regression analysis suggested that METTL7A may serve as an independent prognostic factor in LUAD patients.<br /><br />Based on these findings, the study suggests that METTL7A plays a critical role in promoting cell proliferation, metastasis, and macrophage polarization in LUAD. These findings provide potential therapeutic targets for the treatment of LUAD.

Asset Subtitle

Junfan Pan

Meta Tag

Speaker Junfan Pan

Topic Screening & Early Detection: Biomarkers/Imaging Technology

Keywords

METTL7A protein

lung adenocarcinoma

prognostic value

tumor immunity

METTL7A expression patterns

LUAD grade

LUAD stage

immune response regulation signaling pathways

cell proliferation

therapeutic targets