2023 World Conference on Lung Cancer (Posters)-EP04.04. Ten-year CTNB Data Indicate Its Usefulness and Safety, Especially Salvage Situation after Bronchoscopy without Diagnosis

EP04.04. Ten-year CTNB Data Indicate Its Usefulness and Safety, Especially Salvage Situation after Bronchoscopy without Diagnosis - PDF(Slides)

Back to course

Pdf Summary

A study conducted over a 10-year period at a hospital in Japan analyzed the usefulness and safety of computed tomography assisted needle biopsy (CTNB) for diagnosing thoracic malignancies. The study found that CTNB was particularly effective in salvage situations after bronchoscopy without a diagnosis. The procedure was performed by pulmonologists in 93% of cases, with the remaining 7% conducted by radiologists under the order of surgeons. <br /><br />The study included data from 183 patients who received thoracic CTNB between January 2013 and December 2022. The histological diagnosis rate was 90%, with meaningful diagnoses obtained in 165 cases. The breakdown of diagnoses showed a variety of thoracic malignancies, including adenocarcinoma, squamous cell carcinoma, non-small cell lung cancer, small cell lung cancer, thymoma, thymic cancer, mesothelioma, lymphoma, and others. <br /><br />The study also looked at the baseline characteristics of the patients, including age, sex, performance status, location and size of the target, and the number of nodules or tumors. The stage of lung cancer and the choice of therapy varied, with approximately 50% of cases classified as stage IV and the most common therapy being cytotoxic chemotherapy.<br /><br />The study reported complications associated with CTNB, including major and minor pneumothorax, hemoptysis, fever, and vasovagal reflux. However, the overall safety profile of CTNB was considered satisfactory, with no cases of air embolism observed.<br /><br />The study also discussed the assessment and further improvement of CTNB techniques. It referenced studies from Russia, the United States, Austria, and China that highlighted the accuracy and safety of CTNB, as well as the potential for improving needle choice and incorporating new techniques such as aspiration-type needles and rapid on-site evaluation.<br /><br />In conclusion, the study found that CTNB was a useful and safe procedure for diagnosing thoracic malignancies, especially in salvage situations after unsuccessful bronchoscopy. It emphasized the importance of pursuing CTNB trials, particularly in cases where bronchoscopy did not yield a diagnosis. The study also highlighted the increasing importance of cancer-related gene panels and the potential for enhancing patient outcomes through the exploration of novel CTNB technologies.

Asset Subtitle

Yuki Misumi

Meta Tag

Speaker Yuki Misumi

Topic Screening & Early Detection: Nodule Management

Keywords

CTNB

diagnosing thoracic malignancies

salvage situations

bronchoscopy

histological diagnosis

complications

pneumothorax

needle choice

rapid on-site evaluation

cancer-related gene panels