2023 World Conference on Lung Cancer (Posters)-EP04.05. Incidentally-Detected Lung Cancer in Persons Too Young or Too Old for Lung Cancer Screening.

EP04.05. Incidentally-Detected Lung Cancer in Persons Too Young or Too Old for Lung Cancer Screening. - PDF(Slides)

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This study examined the incidence of lung cancer and survival outcomes in individuals who were either too young or too old for lung cancer screening. The authors compared a cohort of individuals aged 35-50 years (young LNP), a cohort of individuals aged 80 years and older (elderly LNP), and a low-dose computer tomographic (LDCT) screening cohort. They found that the cumulative incidence of lung cancer diagnosis was similar between the young LNP cohort and the LDCT cohort with baseline Lung-RADS scores of 1 and 2. However, the cumulative incidence of lung cancer was higher in the elderly LNP cohort, exceeding Lung-RADS 3 but lower than Lung-RADS 4. Clinical stage at diagnosis was also found to differ among the groups, with a higher proportion of stage IV cases in the young and elderly LNP cohorts compared to the LDCT cohort. Overall survival was significantly worse in the LNP cohorts, with a median survival of 1.99 years in the elderly LNP cohort compared to not reached in the LDCT and young LNP cohorts. The study also noted differences in demographic and clinical characteristics among the cohorts, with a higher proportion of Black individuals and those with Medicaid or no insurance in the young LNP cohort compared to the LDCT and elderly LNP cohorts. Active cigarette use was also more prevalent in the LDCT cohort. These findings suggest that although early detection through LDCT screening can improve survival in lung cancer patients, the benefits may be limited for individuals too young or too old for screening. Further research is needed to better understand the outcomes and management of incidentally-detected lung nodules in these populations.

Asset Subtitle

Raymond Osarogiagbon

Meta Tag

Speaker Raymond Osarogiagbon

Topic Screening & Early Detection: Program Design

Keywords

lung cancer

survival outcomes

lung cancer screening

incidence

age groups

Lung-RADS scores

clinical stage

overall survival

demographic characteristics

cigarette use