2023 World Conference on Lung Cancer (Posters)-EP05.01. Lung Cancer in Combined Pulmonary Fibrosis and Emphysema Syndrome Patients. A Complication or a Comorbidity?

EP05.01. Lung Cancer in Combined Pulmonary Fibrosis and Emphysema Syndrome Patients. A Complication or a Comorbidity? - PDF(Abstract)

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This presentation discusses lung cancer in patients with Combined Pulmonary Fibrosis and Emphysema (CPFE) syndrome. CPFE syndrome is characterized by upper lung predominant emphysema and lower lung predominant fibrosis, and all patients are smokers or ex-smokers, putting them at high risk for developing lung cancer. The study retrospectively reviewed the medical records of CPFE patients diagnosed with lung cancer from 2010 to 2016. <br /><br />Out of a total of 18 CPFE cases, 4 male patients were diagnosed with lung cancer. The lung cancers were peripheral primary lung cancers, with 3 cases being squamous cell carcinoma and 1 case being small cell carcinoma. The patients with lung cancer had a higher unit pack-years (UPY) smoking value, lower pulmonary functional state, and higher values of pulmonary hypertension compared to other CPFE patients. Two patients with lung cancer in this study have died, and their mean survival time was 2 years.<br /><br />The study concludes that lung cancer in CPFE syndrome represents a specific entity with a poor prognosis. It emphasizes the severe impact of tobacco-related diseases and suggests that CPFE may be an independent risk factor for lung cancer. However, the small number of patients in this study highlights the need for further research to confirm the relationship between CPFE and lung cancer.<br /><br />Overall, this presentation highlights the importance of understanding the relationship between CPFE syndrome, smoking, and lung cancer. It provides insights into the prognosis and characteristics of lung cancer in CPFE patients, shedding light on a specific subgroup of lung cancer patients.

Asset Subtitle

Jolanda Nikolla

Meta Tag

Speaker Jolanda Nikolla

Topic Pulmonology & Staging

Keywords

lung cancer

CPFE syndrome

emphysema

fibrosis

smokers

squamous cell carcinoma

small cell carcinoma

pack-years

prognosis

tobacco-related diseases