2023 World Conference on Lung Cancer (Posters)-EP06.02. Pan-cancer Analyses Reveal Immune Infiltration and Clinical Outcomes of IL7R

EP06.02. Pan-cancer Analyses Reveal Immune Infiltration and Clinical Outcomes of IL7R - PDF(Abstract)

Pdf Summary

The study presented at the WCLC 2023 conference investigated the role of IL7R as a biomarker for immunotherapy in various cancer types. The researchers aimed to understand the impact of IL7R expression on treatment efficacy and patient outcomes. They analyzed data from multiple treatment cohorts and performed survival analyses and function enrichment on TCGA pan-cancer samples.<br /><br />The results showed that while IL7R did not have a universal prognostic impact on overall survival, patients with high IL7R expression tended to have better response rates and longer survival times in immunotherapy cohorts. These patients also displayed higher levels of immune and stromal cell infiltration in the tumor microenvironment, indicating an immune-hot environment. Furthermore, IL7R high expression was associated with more immune pathway enrichment and a higher proportion of memory T cells and M1 cells in the TME.<br /><br />The study also found that IL7R high expression was correlated with increased genome instability and upregulation of immune-related molecules. Additionally, single-cell analyses and cell experiments revealed that T cells with high IL7R expression were more likely to be non-terminal T cells.<br /><br />Based on these findings, the researchers concluded that IL7R plays a crucial role in shaping the diversity of the tumor microenvironment across different cancer types. They suggest that IL7R may serve as a potential clinically relevant biomarker for predicting immunotherapy benefits.<br /><br />Overall, this study highlights the importance of biomarkers in evaluating treatment efficacy in immunotherapy and provides insights into the role of IL7R in the immune response to cancer.

Asset Subtitle

Jiafeng Liang

Meta Tag

Speaker Jiafeng Liang

Topic Pathology & Biomarkers: Biomarkers for Immuno-oncology

Keywords

IL7R

biomarker

immunotherapy

cancer types

treatment efficacy

patient outcomes

tumor microenvironment

response rates

memory T cells

genome instability