2023 World Conference on Lung Cancer (Posters)-EP06.02. Pan-cancer Analyses Reveal Immune Infiltration and Clinical Outcomes of IL7R

EP06.02. Pan-cancer Analyses Reveal Immune Infiltration and Clinical Outcomes of IL7R - PDF(Slides)

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A study conducted by J. Liang and S. Ma at the Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, explored the role of IL7R in the tumor microenvironment (TME) and its effects on immunotherapy. The researchers identified IL7R as a critical gene in the TME and investigated its clinical efficacy in multiple treatment cohorts. <br /><br />While IL7R did not have a universal prognostic impact on pan-cancer survival, the analysis of immunotherapy cohorts showed that patients with high IL7R expression tended to have higher response rates and longer survival times. These patients also exhibited higher immune and stromal cell infiltration in the TME, indicating an immune-hot environment. Additionally, patients with high IL7R expression had a higher proportion of memory T cells and M1 cells in the TME. <br /><br />Furthermore, IL7R high expression patients had more frequent genome instability and immune molecular upregulation. Single-cell analyses and cell experiments revealed that CD8 T cells with high IL7R expression were more likely to be non-terminal T cells. <br /><br />The study concluded that IL7R plays a crucial role in the diversity formation of the TME across different cancer types and may serve as a potential biomarker for predicting immunotherapy benefits. The findings suggest that IL7R expression can have a significant impact on the response to immunotherapy and survival outcomes.

Asset Subtitle

Jiafeng Liang

Meta Tag

Speaker Jiafeng Liang

Topic Pathology & Biomarkers: Biomarkers for Immuno-oncology

Keywords

IL7R

tumor microenvironment

immunotherapy

clinical efficacy

response rates

survival times

immune-hot environment

memory T cells

M1 cells

genome instability