2023 World Conference on Lung Cancer (Posters)-EP06.02. The Relationship between Pathologic and Molecular Characteristics and PD-L1 Expression in Surgically Resected Non-small Cell Lung Cancer

EP06.02. The Relationship between Pathologic and Molecular Characteristics and PD-L1 Expression in Surgically Resected Non-small Cell Lung Cancer - PDF(Abstract)

Back to course

Pdf Summary

This presentation discusses the relationship between pathological and molecular characteristics and PD-L1 expression in surgically resected non-small cell lung cancer (NSCLC). The advent of molecular-targeted agents and immune checkpoint inhibitors (ICIs) has changed the surgical treatment of NSCLC, but the relationship between these characteristics and PD-L1 expression is still unclear. Understanding this relationship is important for determining appropriate perioperative treatment for NSCLC patients. <br /><br />The study enrolled 376 patients who underwent surgical resection for lung adenocarcinoma and squamous cell carcinoma. The patients' medical and pathology records were reviewed to gather demographic and pathology-specific data. In cases where next-generation sequencing (NGS) analysis was performed, the association between driver gene mutations and PD-L1 expression was examined in lung adenocarcinomas. PD-L1 expression was determined using the tumor proportion score (TPS) and stained using the 22C3 pharmDx assay.<br /><br />The results showed that PD-L1 expression tended to increase as adenocarcinoma progressed, except in Stage 4. In particular, PD-L1 expression was significantly higher in Stage 1 B, 2, and 3 compared to Stage 0. However, there was no significant association between cancer progression and PD-L1 expression in squamous cell carcinoma. Analysis of molecular alterations in adenocarcinoma patients revealed that EGFR mutations had a lower rate of high TPS, especially common mutations (Ex19del and L858R), which accounted for only 4.8%. In contrast, EGFR wild type had a high TPS rate of 21.1%.<br /><br />These findings suggest that there is an association between pathological and molecular genetic features and PD-L1 expression in NSCLC. This provides new insights into the perioperative treatment of NSCLC. The study highlights the importance of understanding the relationship between these characteristics for determining appropriate treatment strategies for NSCLC patients.

Asset Subtitle

Atsushi Ito

Meta Tag

Speaker Atsushi Ito

Topic Pathology & Biomarkers: Biomarkers for Immuno-oncology

Keywords

pathological characteristics

molecular characteristics

PD-L1 expression

surgically resected

NSCLC

molecular-targeted agents

immune checkpoint inhibitors

perioperative treatment

EGFR mutations

genetic features