2023 World Conference on Lung Cancer (Posters)-EP06.02. The Relationship between Pathologic and Molecular Characteristics and PD-L1 Expression in Surgically Resected Non-small Cell Lung Cancer

EP06.02. The Relationship between Pathologic and Molecular Characteristics and PD-L1 Expression in Surgically Resected Non-small Cell Lung Cancer - PDF(Slides)

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A study conducted by Atsushi Ito and colleagues at the Department of Thoracic Surgery, Matsusaka Municipal Hospital in Japan, examined the relationship between pathologic and genetic characteristics and the expression of PD-L1 in surgically resected non-small cell lung cancer (NSCLC). The researchers aimed to gain a better understanding of the clinicopathological characteristics that promote PD-L1 expression in early-stage NSCLC patients.<br /><br />The study included 376 Japanese patients who underwent lung surgery for adenocarcinoma and squamous cell carcinoma. The researchers reviewed the patients' medical and pathology records and performed the Oncomine Dx Targeted Test to determine the presence of driver gene mutations. PD-L1 expression was assessed using the tumor proportion score (TPS).<br /><br />The results showed that invasive pathological factors and disease progression significantly influenced the expression of PD-L1 in adenocarcinoma, but not in squamous cell carcinoma. Additionally, the distribution pattern of PD-L1 expression differed according to the type of driver gene mutation in lung adenocarcinoma.<br /><br />The study provides valuable real-world data that can contribute to the perioperative management of lung adenocarcinoma and squamous cell carcinoma. The findings highlight the importance of understanding the molecular and genetic characteristics of NSCLC to guide treatment decisions and improve patient outcomes.

Asset Subtitle

Atsushi Ito

Meta Tag

Speaker Atsushi Ito

Topic Pathology & Biomarkers: Biomarkers for Immuno-oncology

Keywords

study

PD-L1 expression

NSCLC

adenocarcinoma

squamous cell carcinoma

driver gene mutations

tumor proportion score

invasive pathological factors

disease progression

molecular characteristics