2023 World Conference on Lung Cancer (Posters)-EP06.03. Molecular Alterations in Non-Small Cell Lung Cancer Arising in Emphysematous and Fibrotic Lungs

EP06.03. Molecular Alterations in Non-Small Cell Lung Cancer Arising in Emphysematous and Fibrotic Lungs - PDF(Abstract)

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This study aimed to examine the molecular alterations in non-small cell lung cancer that arises in emphysematous and fibrotic lungs. Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are chronic lung diseases that are associated with an increased risk of lung cancer. The contribution of lung parenchymal remodeling in emphysema and fibrosis to tumorigenesis is not well understood. The researchers analyzed consecutive lung resection specimens from patients with non-small cell carcinoma and histologic evidence of smoking-related emphysema and UIP/IPF. The results of targeted next generation sequencing of the lung cancer were reviewed.<br /><br />The study included 90 patients, with the cases classified into centrilobular emphysema (CLE) and UIP/IPF groups. The most common mutations in the CLE group were KRAS, TP53, EGFR, and MET exon 14 skipping. In the UIP/IPF group, the most common mutation was TP53. There was a higher proportion of male patients in the UIP/IPF group compared to the CLE group.<br /><br />The findings indicate that the majority of non-small cell lung cancer arising in smoking-related emphysematous lungs have different molecular alterations compared to those in the fibrotic lungs of IPF. This suggests a separate contribution to tumorigenesis based on the tissue environment of chronic lung injuries.<br /><br />Overall, this study provides insight into the molecular characteristics of lung cancer in emphysematous and fibrotic lungs, highlighting the importance of understanding the underlying mechanisms in different lung disease contexts.

Asset Subtitle

Yinghan Hsu

Meta Tag

Speaker Yinghan Hsu

Topic Pathology & Biomarkers: Genetic Biomarkers

Keywords

non-small cell lung cancer

emphysematous lungs

fibrotic lungs

chronic obstructive pulmonary disease

COPD

idiopathic pulmonary fibrosis

IPF

lung parenchymal remodeling

tumorigenesis

next generation sequencing