2023 World Conference on Lung Cancer (Posters)-EP06.05. Histopathologic Changes of the Perioperative Pirfenidone Therapy in Lung Cancer with Idiopathic Pulmonary Fibrosis

EP06.05. Histopathologic Changes of the Perioperative Pirfenidone Therapy in Lung Cancer with Idiopathic Pulmonary Fibrosis - PDF(Slides)

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The study evaluated the effects of perioperative administration of pirfenidone (PFD) on fibrosis in patients with lung cancer and idiopathic pulmonary fibrosis (IPF). The expression of periostin, an extracellular matrix protein associated with fibroblast activity, was examined using histopathological images. A total of 34 patients were included in the study, and differences between the PFD administration group and the non-administration group were analyzed.<br /><br />The results indicated that PFD administration may prevent the progression of fibrosis. The histopathological evaluation, including immunostaining with periostin antibody, showed potential for assessing the degree of fibrosis. Inflammatory and fibrotic changes were evaluated using hematoxylin and eosin staining.<br /><br />The patient characteristics were also analyzed. The PFD administration group consisted of 18 patients, while the non-PFD group had 16 patients. The mean age of the PFD group was 71.7, and the majority of the patients were male. The smoking status, diagnostic pattern of UIP (usual interstitial pneumonia), localization of lesions, clinical stage, and pathological stage were also recorded for both groups.<br /><br />Overall survival and relapse-free survival were assessed but did not show significant differences between the PFD administration and non-administration groups.<br /><br />In conclusion, perioperative administration of PFD may have a preventive effect on fibrosis in lung cancer patients with IPF. The evaluation of periostin immunostaining could be useful in assessing the degree of fibrosis. These findings suggest that PFD has potential benefits in managing fibrotic lung diseases such as IPF. Further research and larger studies are needed to confirm these results.

Asset Subtitle

Hodaka Oeda

Meta Tag

Speaker Hodaka Oeda

Topic Pathology & Biomarkers

Keywords

perioperative administration

pirfenidone

fibrosis

lung cancer

idiopathic pulmonary fibrosis

periostin

extracellular matrix protein

fibroblast activity

histopathological images

PFD administration