2023 World Conference on Lung Cancer (Posters)-EP06.05. Immunohistochemical Features in Tissue Microarray in Pleomorphic Carcinoma of the Lungs

EP06.05. Immunohistochemical Features in Tissue Microarray in Pleomorphic Carcinoma of the Lungs - PDF(Abstract)

Pdf Summary

This study examines the expression pattern of integrin-linked kinase (ILK), osteopontin, and dysadherin in pulmonary pleomorphic carcinoma (PPC) and investigates their correlation with patient prognosis. The researchers obtained pleomorphic carcinoma tissue samples from 42 patients undergoing surgical resection. Immunohistochemical staining was performed on the tissue samples, and the expression levels of ILK, osteopontin, and dysadherin were analyzed. The results showed that ILK was expressed in 95.2% of cases, osteopontin in 88.1% of cases, and dysadherin in only 4.8% of cases. The researchers found a significant association between high ILK expression and shorter patient survival, as well as between high osteopontin expression and longer patient survival. These findings suggest that ILK and osteopontin could serve as good prognostic predictors in patients with PPC. Overall, this study sheds light on the understanding of molecular markers in PPC and their potential use in predicting patient outcomes.

Asset Subtitle

Won-Il Choi

Meta Tag

Speaker Won-Il Choi

Topic Pathology & Biomarkers

Keywords

integrin-linked kinase

ILK

osteopontin

dysadherin

pulmonary pleomorphic carcinoma

PPC

patient prognosis

surgical resection

immunohistochemical staining

expression levels