2023 World Conference on Lung Cancer (Posters)-EP06.05. Immunohistochemical Features in Tissue Microarray in Pleomorphic Carcinoma of the Lungs

EP06.05. Immunohistochemical Features in Tissue Microarray in Pleomorphic Carcinoma of the Lungs - PDF(Slides)

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This study examined the expression patterns of integrin-linked kinase (ILK), osteopontin, and dysadherin in pleomorphic carcinoma of the lungs (PPC) and investigated their correlation with patient prognosis. The researchers collected pleomorphic carcinoma specimens from 42 patients who underwent surgical resection of their primary pulmonary tumors. Immunohistochemical stains were performed on formalin-fixed, paraffin-embedded tissue samples to determine the expression levels of ILK, osteopontin, and dysadherin. The results showed that ILK was positively expressed in 95.2% of cases, osteopontin was expressed in 88.1% of cases, and dysadherin was only expressed in 4.8% of cases. Statistical analysis revealed a significant association between high ILK expression and short patient survival, as well as a significant association between high osteopontin expression and long patient survival. However, there was no significant association between high expression of these molecules and other clinico-pathologic parameters such as age, sex, stage, and nodal metastasis. Additionally, organ metastasis was found to be significantly associated with short patient survival. The study concludes that high ILK expression indicates an unfavorable prognosis for PPC patients, while high osteopontin expression indicates a favorable prognosis. Dysadherin was found to not be well expressed in PPC, suggesting it may not play a significant role in the prognosis of PPC patients. This study suggests that ILK and osteopontin can be good prognostic predictors in patients with PPC.

Asset Subtitle

Won-Il Choi

Meta Tag

Speaker Won-Il Choi

Topic Pathology & Biomarkers

Keywords

integrin-linked kinase

ILK

osteopontin

dysadherin

pleomorphic carcinoma

lungs

patient prognosis

surgical resection

immunohistochemical stains

expression levels