2023 World Conference on Lung Cancer (Posters)-EP06.06. Cancer-Associated Fibroblasts and Estrogen Receptor Beta in Lung Cancer with Idiopathic Pulmonary Fibrosis

EP06.06. Cancer-Associated Fibroblasts and Estrogen Receptor Beta in Lung Cancer with Idiopathic Pulmonary Fibrosis - PDF(Slides)

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In this study, the researchers investigated the relationship between fibrosis factors, specifically cancer-associated fibroblasts (CAFs) and transforming growth factor (TGF) β, and estrogen receptor (ER) in lung cancer with idiopathic pulmonary fibrosis (IPF). They evaluated 19 samples of lung cancer with IPF and compared the expression of TGF β, vascular endothelial growth factor (VEGF) receptor, S100A4 (a fibrosis factor), and ER β using immunohistochemistry staining. They also compared the expression of these factors between early-stage and advanced-stage lung cancer.<br /><br />The results showed that there was no significant difference in the expression of TGF β and ER β between normal lung, fibrosis, and cancer areas. However, the expression of VEGF receptor and S100A4 was significantly higher in fibrosis areas compared to the other two areas. Additionally, in the areas evaluated, the expression of TGF β, S100A4, and ER β was higher in advanced-stage lung cancer compared to early-stage lung cancer.<br /><br />Based on these findings, the researchers concluded that although previous studies have shown an interaction between ER and TGF β in other organs, this interaction is unclear in the lung. They also noted that both TGF β and ER β had low expression in the cancer area. Further studies are needed to confirm this interaction and understand its implications.

Asset Subtitle

Eiji Nakajima

Meta Tag

Speaker Eiji Nakajima

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

fibrosis factors

cancer-associated fibroblasts

TGF β

ER β

lung cancer

idiopathic pulmonary fibrosis

immunohistochemistry staining

VEGF receptor

S100A4

expression