2023 World Conference on Lung Cancer (Posters)-EP06.06. Fibronectin Promotes Tumor Angiogenesis and Progression of Non-small-Cell Lung Cancer

EP06.06. Fibronectin Promotes Tumor Angiogenesis and Progression of Non-small-Cell Lung Cancer - PDF(Abstract)

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This presentation discussed the role of fibronectin, an extracellular matrix protein, in promoting tumor angiogenesis and progression in non-small-cell lung cancer (NSCLC). The study aimed to further elucidate the mechanisms by which fibronectin contributes to NSCLC progression. The researchers used public datasets and immunohistochemistry experiments to assess the prognostic significance of fibronectin in NSCLC patients. In vitro and in vivo experiments were then conducted to evaluate the effects of fibronectin on tumor growth, metastasis, and angiogenesis in NSCLC.<br /><br />The results showed that fibronectin expression was higher in cancer tissues compared to normal tissues in NSCLC patients, and higher fibronectin expression predicted a poor prognosis. Fibronectin was found to enhance tumor growth, metastasis, and angiogenesis in NSCLC by promoting epithelial-mesenchymal transition (EMT) and maintaining stemness of NSCLC cells. Fibronectin activated the FAK and MAPK/ERK signaling pathways, and WISP3 was identified as a potential target gene of fibronectin. Further investigation revealed that WISP3 activated the Wnt signaling pathway, and knockdown of WISP3 blocked the effects of fibronectin on NSCLC cells.<br /><br />Additionally, fibronectin was shown to enhance the transcription of WISP3 by promoting the binding of HIF-1α to the promoter region of WISP3 in NSCLC cells. This led to the activation of the Wnt signaling pathway and ultimately promoted tumor growth, metastasis, and angiogenesis in NSCLC.<br /><br />In conclusion, this study provided insights into the mechanism by which fibronectin contributes to NSCLC progression. Fibronectin activated downstream signaling pathways and mediated the accumulation of HIF-1α, which facilitated the transcription of WISP3. This, in turn, activated the Wnt signaling pathway and enhanced tumor growth, metastasis, and angiogenesis in NSCLC.

Asset Subtitle

Guanghui Gao

Meta Tag

Speaker Guanghui Gao

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

fibronectin

tumor angiogenesis

NSCLC

prognostic significance

epithelial-mesenchymal transition

stemness

FAK

MAPK/ERK signaling

WISP3

Wnt signaling