2023 World Conference on Lung Cancer (Posters)-EP06.06. Insulin Like Growth Factor 2 mRNA Binding Protein3 is a Novel Post-Transcriptional Regulator of Lung Adenocarcinoma Malignancy

EP06.06. Insulin Like Growth Factor 2 mRNA Binding Protein3 is a Novel Post-Transcriptional Regulator of Lung Adenocarcinoma Malignancy - PDF(Slides)

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IGF2BP3, a gene involved in mRNA modifications, is found to be highly expressed in various types of tumors, including lung adenocarcinoma (LUAD). In this study, the researchers aimed to explore the functional role of IGF2BP3 in LUAD. They analyzed IGF2BP3 expression data from the TCGA LUAD cohort and found that it was significantly higher in LUAD tissues compared to normal lung tissues. Furthermore, high expression of IGF2BP3 was associated with shorter overall survival, progression-free survival, and progression-free interval.<br /><br />The researchers also investigated the association of IGF2BP3 with tumor pathways and tumor microenvironment (TME). They found that IGF2BP3 expression was correlated with tumor metastasis, angiogenesis, quiescence, and differentiation in single-cell sequencing data of LUAD. Additionally, functional enrichment analysis revealed that IGF2BP3 was significantly associated with several pathways, including estrogen, hypoxia, p53, PI3K, WNT, and MAPK pathways. It was also associated with 24 published TME signatures.<br /><br />Furthermore, the researchers found that IGF2BP3 may regulate the tricarboxylic acid cycle, influencing amino acids, fatty acids, and glucose metabolism. It was also associated with drug sensitivity, with IGF2BP3 RNA editing being significantly correlated with the sensitivity of several drugs commonly used in LUAD treatment.<br /><br />To further understand the functional role of IGF2BP3, the researchers performed knockdown and overexpression experiments in LUAD cells. They observed that IGF2BP3 positively correlated with the cloning, migration, and invasion abilities of LUAD cells.<br /><br />In conclusion, this study highlights the significance of IGF2BP3 in LUAD. The high expression of IGF2BP3 indicates poorer prognosis and is associated with multiple tumor pathways, as well as the proliferation, metastasis, invasion, TME, and drug sensitivity of LUAD. This research provides valuable insights into the role of IGF2BP3 in LUAD and may contribute to the development of targeted therapies for this disease.

Asset Subtitle

Xuequan Wang

Meta Tag

Speaker Xuequan Wang

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

IGF2BP3

LUAD

tumors

survival

metastasis

pathways

TME

drug sensitivity

RNA editing

proliferation