2023 World Conference on Lung Cancer (Posters)-EP06.06. Surveying for Lung Cancer after Idiopathic Pulmonary Fibrosis at Pham Ngoc Thach Hospital - Viet Nam in 5 year (2017 - 2021)

EP06.06. Surveying for Lung Cancer after Idiopathic Pulmonary Fibrosis at Pham Ngoc Thach Hospital - Viet Nam in 5 year (2017 - 2021) - PDF(Slides)

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A study was conducted to investigate the development of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) at Pham Ngoc Thach Hospital in Vietnam over a five-year period from 2017 to 2021. The objectives of the research were to determine the proportion of patients with lung cancer after IPF and identify the clinical, pathological, and treatment factors in this patient group.<br /><br />The study was retrospective and included all IPF patients hospitalized during the five-year period. The total number of IPF cases was 136, and out of those, 49 cases (36.03%) also had lung cancer. The majority of cases were males (63.27%) and smokers (65.31%). Adenocarcinoma was the most common histological type of lung cancer (55%).<br /><br />The research also analyzed the time from diagnosis of IPF to the diagnosis of lung cancer, which ranged from 3 to 24 months. The right lung, particularly the lower lobe, was more affected by lung cancer among IPF patients. Genetic variations, such as mutations in genes like EGFR, KRAS, and ALK, were observed in the lung cancer cases associated with IPF.<br /><br />In terms of treatment, double platinum chemotherapy was the most common approach, followed by generation I-II TKIs and immunotherapy. Combination treatment of cancer and anti-fibrotic medicines was also utilized in some cases.<br /><br />Overall survival analysis showed a low average survival time of around 5 months. The study concluded that IPF is a significant factor in the development of lung cancer, with a relatively high rate of lung cancer in IPF patients. The majority of cases were male smokers, and adenocarcinoma was the most common histological type. The study also highlighted the dominant presence of genetic mutations in EGFR, KRAS, and ALK genes in the lung cancer cases associated with IPF. The research noted challenges in treating and monitoring these patients and emphasized the importance of further investigation in this phenotypic comorbidity of lung cancer and IPF.

Asset Subtitle

Nguyen Lam

Meta Tag

Speaker Nguyen Lam

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

lung cancer

idiopathic pulmonary fibrosis

retrospective study

adenocarcinoma

genetic variations

chemotherapy

immunotherapy

overall survival analysis

male smokers

phenotypic comorbidity