2023 World Conference on Lung Cancer (Posters)-EP06.06. The Expression of MIR-320B in Extracellular Vesicles as a Prognostic factor for Non-small Cell Lung Carcinoma

EP06.06. The Expression of MIR-320B in Extracellular Vesicles as a Prognostic factor for Non-small Cell Lung Carcinoma - PDF(Abstract)

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This study investigated the expression of miR-320b in extracellular vesicles (EVs) as a prognostic factor for non-small cell lung carcinoma (NSCLC). The study included 16 NSCLC patients who underwent therapy and aimed to compare the expression of miR-320b in different response groups (complete response, partial response, stable disease, and progressive disease). Blood samples were collected before and after therapy, and EV isolation and analysis were performed.<br /><br />The results showed that after therapy, the levels of miR-320b increased, although not significantly. The partial response group had a 28% decrease in miR-320b levels, the stable disease group had a 21% decrease, and the progressive disease group had a 29% increase. However, there was no significant relationship between miR-320b levels and treatment response. Additionally, there was no significant difference in miR-320b levels between patients undergoing chemotherapy and tyrosine kinase inhibitor therapy.<br /><br />The findings suggest that the decrease in miR-320b expression in the stable disease and partial response groups and the increase in the progressive disease group may occur as a response mechanism in the tumor cell microenvironment to the therapeutic effects. This reflects efforts to inhibit the progression of cancer cells.<br /><br />In summary, this study evaluated the expression of miR-320b in extracellular vesicles as a prognostic factor for NSCLC. The results showed changes in miR-320b levels after therapy, but these changes were not significantly associated with treatment response. Further research is needed to fully understand the role of miR-320b in NSCLC prognosis and its potential as a biomarker.

Asset Subtitle

Wily Ariawan

Meta Tag

Speaker Wily Ariawan

Topic Pathology & Biomarkers: Prognostic Biomarkers

Keywords

miR-320b

extracellular vesicles

prognostic factor

non-small cell lung carcinoma

NSCLC

response groups

therapy

blood samples

EV isolation

treatment response