2023 World Conference on Lung Cancer (Posters)-EP07.01. Assessing Morphometric Complexity in Lung Parenchyma of NSCLC Patients with IPF Undergoing Radiotherapy

EP07.01. Assessing Morphometric Complexity in Lung Parenchyma of NSCLC Patients with IPF Undergoing Radiotherapy - PDF(Slides)

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A study was conducted to assess the morphometric complexity in the lung parenchyma of patients with non-small cell lung cancer (NSCLC) and underlying idiopathic pulmonary fibrosis (IPF) who underwent radiotherapy (RT). It was observed that patients with IPF are more susceptible to pulmonary toxicity after RT. Previous studies have shown that lower morphometric complexity in the lung indicates a worse prognosis in patients with chronic obstructive pulmonary disease (COPD). The objective of this study was to establish a framework for utilizing complexity measurements for prognosis.<br /><br />The study included five NSCLC patients with underlying IPF who were treated with definitive RT. The input data consisted of chest CT scans, lung masks, and contours of different radiation doses. The measurement of morphometric complexity was done using the normal attenuation area (NAA) between -950 HU and -700 HU, and box-counting fractal dimension analysis. The outcome of interest was severe radiation pneumonitis.<br /><br />The clinical courses of the patients were tracked, and it was found that the lung parenchyma exposed to higher radiation doses had lower morphometric complexity. Two patients who experienced severe radiation pneumonitis had the lowest mean fractal dimensions.<br /><br />In summary, the study developed a method to measure morphometric complexity in NSCLC patients with IPF and utilized it for prognosis. The findings suggest that lower morphometric complexity may indicate a higher risk of pulmonary toxicity after radiotherapy in patients with underlying IPF. The study was supported by Korea University Guro Hospital, Korea University Medicine, and the National Research Foundation of Korea.

Asset Subtitle

Jeongeun Hwang

Meta Tag

Speaker Jeongeun Hwang

Topic Early-Stage NSCLC: Best Practice

Keywords

morphometric complexity

lung parenchyma

non-small cell lung cancer

NSCLC

idiopathic pulmonary fibrosis

IPF

radiotherapy

pulmonary toxicity

chronic obstructive pulmonary disease

COPD