2023 World Conference on Lung Cancer (Posters)-EP07.01. Lead-Time Bias in Surgically Resected Non-Small Cell Lung Cancer (NSCLC) Diagnosed Through Different Pathways of Care

EP07.01. Lead-Time Bias in Surgically Resected Non-Small Cell Lung Cancer (NSCLC) Diagnosed Through Different Pathways of Care - PDF(Slides)

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This study examined the presence of lead-time bias in surgically resected non-small cell lung cancer (NSCLC) diagnosed through different pathways of care. Lead-time bias refers to the overestimation of survival benefit due to the early detection of indolent cancers. The researchers compared the survival of stage I NSCLC patients diagnosed through low-dose computer tomographic lung cancer screening (LDCT), Lung Nodule Programs (LNP), and non-program-based (NPB) pathways.<br /><br />The study included 1,800 patients, with 116 diagnosed through LDCT, 378 through LNP, and 1,306 through NPB pathways. The patients in the LDCT, LNP, and NPB groups had different demographic and clinical characteristics, such as age, gender, smoking history, comorbidity scores, and tumor types.<br /><br />The overall 5-year survival rates were 92% for LDCT-diagnosed patients, 77% for LNP-diagnosed patients, and 69% for NPB-diagnosed patients, indicating a significant difference in survival among the groups. However, when comparing only stage I NSCLC patients, there was no significant difference in survival between LNP and NPB groups.<br /><br />The findings suggest that lead-time bias was not evident in NSCLC diagnosed through LNP, unlike LDCT-diagnosed NSCLC. The authors propose that implementing LNP may lead to a greater population-level reduction in mortality, highlighting the need for further prospective studies.<br /><br />This study provides insights into the impact of different pathways of care on the survival of NSCLC patients. It suggests that LNP may offer potential benefits in improving survival outcomes, warranting further investigation.

Asset Subtitle

Raymond Osarogiagbon

Meta Tag

Speaker Raymond Osarogiagbon

Topic Early-Stage NSCLC: Best Practice

Keywords

lead-time bias

non-small cell lung cancer

NSCLC

surgical resection

pathways of care

low-dose computer tomographic lung cancer screening

Lung Nodule Programs

non-program-based

survival rates

stage I NSCLC