2023 World Conference on Lung Cancer (Posters)-EP07.01. Long Term Outcomes beyond Five Years after Pulmonary Resection for Non Small Cell Lung Cancer

EP07.01. Long Term Outcomes beyond Five Years after Pulmonary Resection for Non Small Cell Lung Cancer - PDF(Slides)

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A study conducted by Tetsuya Mizuno and colleagues aimed to identify candidates for long-term surveillance after non-small cell lung cancer (NSCLC) resection. The study included 978 NSCLC patients who underwent pulmonary resection between 2002 and 2015 and survived without recurrence for five years. The researchers analyzed various variables including age, sex, smoking history, preoperative serum CEA levels, surgical procedure, histology, pN status, presence of adjuvant therapy, development of recurrence, and development of metachronous malignancies.<br /><br />The study found that late recurrence beyond five years was observed in 1.8-11% of patients with resected NSCLC. The overall survival rate beyond five years post-surgery was 89.1% and the disease-free survival rate was 94.4%. Factors such as pN status, preoperative serum CEA levels, and histology were significantly associated with recurrence-free survival beyond five years post-surgery.<br /><br />In terms of metachronous malignancies, the study found that the incidence of late metachronous malignancies beyond five years post-surgery was 16.3%. The most common primary organs affected were the lung, stomach, colorectum, and urinary tract.<br /><br />Based on these findings, the researchers concluded that long-term surveillance for recurrence beyond five years may have limited usefulness, especially in patients with pN0 adenocarcinoma and/or non-adenocarcinoma. The study highlights the importance of considering individual patient characteristics when determining the need for long-term surveillance after NSCLC resection. Further research is needed to better understand the long-term outcomes and factors affecting them in NSCLC patients.

Asset Subtitle

Tetsuya Mizuno

Meta Tag

Speaker Tetsuya Mizuno

Topic Early-Stage NSCLC: Best Practice

Keywords

non-small cell lung cancer

NSCLC

pulmonary resection

recurrence

survival rate

metachronous malignancies

pN status

preoperative serum CEA levels

histology

long-term surveillance