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2023 World Conference on Lung Cancer (Posters)
EP07.01. Stereotactic Body Radiation Therapy for P ...
EP07.01. Stereotactic Body Radiation Therapy for Patients with Early-Stage Non-small Cell Lung Cancer Inoperable - PDF(Slides)
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This research article discusses the use of stereotactic body radiation therapy (SBRT) as an alternative treatment for early-stage non-small cell lung cancer (NSCLC) in patients who cannot undergo surgery. The study aims to evaluate the outcomes of SBRT in patients with inoperable peripheral tumors.<br /><br />The study protocol includes clinical examination, imaging tests, tumor biopsy, and multidisciplinary tumor board consultation. The patients are followed up and evaluated for progression-free survival, objective response rate, overall survival, and toxicity.<br /><br />The study found that SBRT had promising results, with a median progression-free survival of 29.23 months and 2-year and 3-year progression-free survival rates of 59.8% and 42.3% respectively. The overall survival rate ranged from 96.8% at 1 year to 42.1% at 5 years. The SUVmax value before treatment was found to be related to both progression-free survival and overall survival. Disease control at 3 months after SBRT also correlated with improved local control rate and progression-free survival.<br /><br />The adverse effects of SBRT were evaluated, with grade 3 adverse events occurring in 7 patients and grade 4 adverse events in 2 patients. However, none of the patients died as a result of SBRT. Spirometry parameters did not show significant changes before and after SBRT.<br /><br />In conclusion, SBRT is an effective radical treatment option for early-stage NSCLC in patients who are ineligible for surgery. The SUVmax value before treatment and disease control rate at 3 months are predictive of patient survival. SBRT is considered a safe method of treatment.<br /><br />This research article provides valuable insights into the use of SBRT as an alternative treatment for early-stage NSCLC. The findings can potentially contribute to improving the management and outcomes of patients who are ineligible for surgery.
Asset Subtitle
Luan Pham
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Speaker
Luan Pham
Topic
Early-Stage NSCLC: Best Practice
Keywords
stereotactic body radiation therapy
SBRT
alternative treatment
early-stage non-small cell lung cancer
NSCLC
inoperable peripheral tumors
progression-free survival
objective response rate
overall survival
toxicity
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