2023 World Conference on Lung Cancer (Posters)-EP07.01. The Relationship of FDG PET-SUVm and Glucose Metabolism and Contribution to Early-Stage Non-Small Cell Lung Cancer Survival

EP07.01. The Relationship of FDG PET-SUVm and Glucose Metabolism and Contribution to Early-Stage Non-Small Cell Lung Cancer Survival - PDF(Abstract)

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This study investigates the relationship between FDG PET-SUVm (standard uptake value) and glucose metabolism in early-stage non-small cell lung cancer (NSCLC). The researchers conducted a prospective trial with NSCLC patients who underwent pre-operative FDG-PET imaging and were infused with 13C-labeled glucose intraoperatively. Tissue samples were analyzed to measure glycolytic tumor metabolism.<br /><br />The study included 225 patients, of which 66 were infused with 13C glucose. The overall survival of the patients was 37 months. The results showed an inverse relationship between SUVm and glucose enrichment, indicating that SUVm does not provide sufficient information about tumor glycolysis. However, SUVm was positively correlated with the proliferation index (MIB1), tumor diameter, and Lactate/3-Phosphoglycerate (3-PG) enrichment. Survival analysis showed that Lactate/3PG enrichment ratios predicted a poorer outcome.<br /><br />The characteristics of the patient cohort revealed that most patients were female, with a median age of 67 years. The majority had a smoking history, and the most common stage and grade were stage 1 and grade 2, respectively. The median tumor size was 2.6 cm, and the most common subtype was adenocarcinoma. Lobectomy was the most common surgical procedure.<br /><br />In conclusion, this study suggests that SUVm does not provide sufficient information about tumor glycolysis in early-stage NSCLC. Lactate/3PG enrichment ratios may be a better predictor of outcome. These findings have implications for the use of FDG-PET imaging and highlight the importance of further research on the relationship between glucose metabolism and NSCLC.

Asset Subtitle

Kemp Kernstine

Meta Tag

Speaker Kemp Kernstine

Topic Early-Stage NSCLC: Best Practice

Keywords

FDG PET-SUVm

glucose metabolism

non-small cell lung cancer

prospective trial

glycolytic tumor metabolism

Lactate/3-Phosphoglycerate

patient cohort

tumor size

adenocarcinoma

lobectomy