2023 World Conference on Lung Cancer (Posters)-EP07.01. The Relationship of FDG PET-SUVm and Glucose Metabolism and Contribution to Early-Stage Non-Small Cell Lung Cancer Survival

EP07.01. The Relationship of FDG PET-SUVm and Glucose Metabolism and Contribution to Early-Stage Non-Small Cell Lung Cancer Survival - PDF(Slides)

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A study was conducted to understand the relationship between glucose metabolism and maximum standard uptake value (SUVm) in early-stage non-small cell lung cancer (NSCLC) and its impact on survival. The study involved NSCLC patients who underwent pre-operative FDG-PET imaging and were infused with 13C-labeled glucose during surgery. The resected tissue samples were then analyzed to measure glycolytic tumor metabolism.<br /><br />The results showed that SUVm did not correlate with 13C glycolytic intermediate enrichment, indicating that SUVm does not provide sufficient information about tumor glycolysis. However, there was a positive correlation between SUVm and the tumor proliferation index (MIB1), tumor diameter, and lactate/3-phosphoglycerate (3-PG) enrichment. This suggests that SUVm may be associated with other aspects of tumor biology, rather than glucose metabolism specifically.<br /><br />The overall survival of the patients was found to be 37 months. Additionally, the study found that higher lactate/3-PG enrichment ratios were associated with poorer outcomes. This suggests that lactate production may play a role in the aggressiveness and progression of early-stage NSCLC.<br /><br />The study highlights the limitations of using SUVm as a measure of glucose metabolism in NSCLC. It suggests that additional metabolic markers, such as lactate/3-PG enrichment ratios, may provide more insights into tumor biology and prognosis. Further research is needed to better understand the relationship between SUVm and glucose metabolism in NSCLC and its impact on patient outcomes.

Asset Subtitle

Kemp Kernstine

Meta Tag

Speaker Kemp Kernstine

Topic Early-Stage NSCLC: Best Practice

Keywords

glucose metabolism

SUVm

NSCLC

glycolytic tumor metabolism

tumor proliferation index

MIB1

lactate/3-phosphoglycerate

3-PG enrichment

overall survival

metabolic markers