2023 World Conference on Lung Cancer (Posters)-EP07.02. Evaluation of the Efficacy of Oral Bacterial Lysates in Patients with High-risk Lung Nodules Detected by CT Screening

EP07.02. Evaluation of the Efficacy of Oral Bacterial Lysates in Patients with High-risk Lung Nodules Detected by CT Screening - PDF(Slides)

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The study evaluated the efficacy of oral bacterial lysates in patients with high-risk lung nodules detected by CT screening. Pulmonary nodules have a potential for malignant transformation, and surgery is currently the only effective treatment. The researchers conducted a retrospective population-based study to determine the changes in pulmonary nodules during follow-up in patients with chronic bronchitis combined with high-risk pulmonary nodules detected by CT screening. <br /><br />They enrolled 103 consecutive subjects who visited the hospital for chronic bronchitis and had high-risk ground glass pulmonary nodules detected by CT. Out of these patients, 44 received oral bacterial lysates treatment, while the remaining patients received a routine clinical protocol. An AI automated diagnostic algorithm was used to manage the follow-up of the lung nodules, with the primary endpoint being changes in high-risk ground glass nodules detected on baseline thin-section CT scans after a 6-month follow-up.<br /><br />The results showed that patients taking oral bacterial lysates had a reduced probability of clinical progression of high-risk pulmonary nodules compared to the controls. Additionally, there was a slower trend of nodule volume increase in the lysates group compared to the controls. This suggests an inhibitory effect of bacterial lysates on malignant pulmonary nodules.<br /><br />In conclusion, oral administration of bacterial lysates improves clinical outcomes and slows the trend of invasion in patients with high-risk pulmonary nodules detected by CT screening. The study represents a phase I and phase II trial of a chemoimmune intervention in this type of patient.

Asset Subtitle

Dawei Yang

Meta Tag

Speaker Dawei Yang

Topic Early-Stage NSCLC: New Technology & Innovations

Keywords

oral bacterial lysates

high-risk lung nodules

CT screening

malignant transformation

surgery

retrospective study

population-based study

chronic bronchitis

ground glass pulmonary nodules

AI automated diagnostic algorithm