2023 World Conference on Lung Cancer (Posters)-EP07.02. Hypofractionated Radiation Therapy vs Stereotactic Body Radiation Therapy for Ultra-Central Lung Tumors

EP07.02. Hypofractionated Radiation Therapy vs Stereotactic Body Radiation Therapy for Ultra-Central Lung Tumors - PDF(Slides)

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This study aimed to evaluate different radiotherapy (RT) approaches for treating ultra-central lung tumors (UCLT) and determine the optimal dose and fractionation. The researchers conducted a retrospective study on patients who underwent RT for UCLT between 2008 and 2018. The patients included in the study had tumors located close to critical structures or were deemed medically inoperable. Two RT approaches were evaluated: hypofractionated (HF) schedules consisting of 10-20 fractions and stereotactic body radiotherapy (SBRT) consisting of 8 fractions. The study analyzed overall and progression-free survival rates as well as toxicity and response assessment.<br /><br />The results showed that both HF and SBRT were safe and effective treatments for UCLT. There were no significant differences in overall survival or toxicities between the two groups, although progression-free survival appeared to be better in the SBRT group. However, due to the retrospective nature of the study and the inherent biases in patient selection, clear conclusions could not be drawn. Patients with larger tumors and closer proximity to central anatomy appeared to benefit more from HF treatment. Grade 1-2 pneumonitis and esophagitis rates were higher in the HF group compared to the SBRT group. There were also a few severe toxicity events, including one grade 3 esophagitis requiring admission and one grade 5 bronchopulmonary hemorrhage, both in the HF group.<br /><br />In conclusion, both HF and SBRT are viable treatment options for UCLT. Further research is needed to better define the optimal dose selection for these cases. This study provides valuable information on treatment outcomes and toxicities associated with different RT approaches for UCLT, but the findings should be interpreted with caution due to the limitations of the retrospective study design.

Asset Subtitle

Rui Song

Meta Tag

Speaker Rui Song

Topic Early-Stage NSCLC: New Technology & Innovations

Keywords

radiotherapy approaches

ultra-central lung tumors

optimal dose

fractionation

retrospective study

hypofractionated schedules

stereotactic body radiotherapy

overall survival

progression-free survival

toxicity assessment