2023 World Conference on Lung Cancer (Posters)-EP07.03. Effect of Lymph Node Dissection on Recurrence and Survival Following Thoracoscopic Segmentectomy for Early-Stage Non-small Cell Lung Cancer

EP07.03. Effect of Lymph Node Dissection on Recurrence and Survival Following Thoracoscopic Segmentectomy for Early-Stage Non-small Cell Lung Cancer - PDF(Slides)

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A study was conducted to determine the impact of lymph node dissection on recurrence and survival in patients undergoing thoracoscopic segmentectomy for early-stage non-small cell lung cancer (NSCLC). The study included 158 patients who underwent video-assisted thoracoscopic surgery (VATS) segmentectomy between January 2008 and December 2022.<br /><br />The results showed that the median number of lymph nodes dissected was 9, with a range of 5-11. The follow-up period was 3.3 years. The study found that the number of lymph nodes dissected did not have a significant impact on recurrence or overall survival after thoracoscopic segmentectomy for early-stage NSCLC.<br /><br />Various demographic and clinical characteristics were also assessed, including age, gender, smoking status, and comorbidity index. None of these factors were found to be significant predictors of recurrence or survival.<br /><br />In terms of pathological characteristics, tumor size, margin distance, pleural invasion, vascular invasion, and lymphatic vessel invasion were evaluated. Pleural invasion was the only significant factor associated with recurrence.<br /><br />Multivariable Cox regression analysis was also performed to identify independent factors for recurrence-free survival and overall survival. The analysis included factors such as age, pack-years, comorbidity index, tumor localization, tumor size, and pathological stage. However, none of these factors were significant predictors of recurrence or survival.<br /><br />In conclusion, the study found that the number of lymph nodes dissected during thoracoscopic segmentectomy did not impact recurrence or survival for early-stage NSCLC. Other factors, such as pleural invasion, showed a weak association with recurrence. The results of this study provide insights into the surgical management of early-stage NSCLC and suggest that lymph node dissection may not be necessary for all patients undergoing thoracoscopic segmentectomy.

Asset Subtitle

René Petersen

Meta Tag

Speaker René Petersen

Topic Early-Stage NSCLC: Limited Resections & Minimally Invasive Approaches

Keywords

lymph node dissection

recurrence

survival

thoracoscopic segmentectomy

non-small cell lung cancer

NSCLC

video-assisted thoracoscopic surgery

VATS

pathological characteristics

pleural invasion