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2023 World Conference on Lung Cancer (Posters)
EP07.04. ALK Rearrangement Is Associated with Earl ...
EP07.04. ALK Rearrangement Is Associated with Early Lymphatic Spread in Resected LUAD with Negative Preoperative Mediastinal Staging - PDF(Slides)
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Pdf Summary
This study aimed to investigate the risk of upstaging and recurrence in early stage lung adenocarcinoma (LUAD) patients without nodal metastases based on the oncogene addiction status. The study involved patients from five high volume institutions who underwent anatomical resections and systematic lymphadenectomy. The primary endpoint was to identify predictive factors of unexpected nodal metastasis, while the secondary endpoint was disease-free survival (DFS). <br /><br />Results showed that ALK rearrangement was strongly associated with occult nodal metastasis. PD-L1 status greater than or equal to 1% was also significantly linked to occult nodal metastasis. However, ALK rearrangement did not have an impact on DFS. Among ALK rearranged patients, those who were upstaged did not have worse DFS compared to those who were not upstaged. <br /><br />In conclusion, ALK rearrangement is a strong predictive factor of occult nodal metastasis in early stage LUAD with negative preoperative mediastinal staging. PD-L1 status greater than or equal to 1% is also associated with occult nodal metastasis. However, ALK rearrangement does not influence DFS. Additionally, ALK rearranged patients who are upstaged do not have worse DFS compared to those who are not upstaged. These findings provide important insights into the management and prognosis of early stage LUAD patients without evidence of nodal metastases.
Asset Subtitle
Filippo Tommaso Gallina
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Speaker
Filippo Tommaso Gallina
Topic
Early-Stage NSCLC: Progress in Pathology
Keywords
risk
upstaging
recurrence
early stage
lung adenocarcinoma
nodal metastases
ALK rearrangement
PD-L1 status
occult nodal metastasis
disease-free survival
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