2023 World Conference on Lung Cancer (Posters)-EP07.04. Clinicopathological Features and Postoperative Prognosis of Bubble-like Appearance Type Lung Adenocarcinoma

EP07.04. Clinicopathological Features and Postoperative Prognosis of Bubble-like Appearance Type Lung Adenocarcinoma - PDF(Slides)

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This study focuses on the clinicopathological features and postoperative prognosis of a specific type of lung adenocarcinoma called bubble-like appearance (BLA) type lung adenocarcinoma. The authors previously reported on BLA-type lung adenocarcinomas, which are sometimes overlooked because they can be mistaken for old inflammatory lesions. However, the postoperative prognosis of BLA-type lung adenocarcinomas is not well understood.<br /><br />The authors retrospectively reviewed the data of 130 patients with BLA-type lung adenocarcinoma who underwent complete surgical resection between January 2010 and December 2019. They analyzed various patient characteristics, including sex, age, smoking history, tumor size, and preoperative diagnosis. They also examined pathological findings such as tumor type, size, lymphatic and vascular invasion, and EGFR mutation status.<br /><br />The results showed that the CT tumor size was relatively large, but the pathological stage was often downstaged due to the discrepancy between the tumor size and invasive size. The EGFR mutation rate was high at 63.8%. The 5-year recurrence-free survival (RFS) in pathological stage II-III was poor at 27.5%. Smoking history, pN factor (lymph node involvement), and vascular invasion were significant risk factors for recurrence.<br /><br />Overall, the study found that a high percentage of BLA-type lung adenocarcinomas were classified as pathological stage I, despite appearing large on CT scans. However, when lymph node metastasis occurred, careful attention was needed as it was associated with a high recurrence rate.<br /><br />In conclusion, the authors highlight the importance of accurately diagnosing and staging BLA-type lung adenocarcinomas to guide appropriate treatment decisions and follow-up care. They emphasize the need for vigilance in cases of lymph node involvement, as they are associated with a higher risk of recurrence.

Asset Subtitle

Kotaro Murakami

Meta Tag

Speaker Kotaro Murakami

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

clinicopathological features

postoperative prognosis

lung adenocarcinoma

bubble-like appearance

BLA-type

EGFR mutation

recurrence-free survival

smoking history

lymph node involvement

vascular invasion