2023 World Conference on Lung Cancer (Posters)-EP07.04. High-Risk Clinicopathologic and Genomic Features of Recurrence in Stage I Lung Adenocarcinoma

EP07.04. High-Risk Clinicopathologic and Genomic Features of Recurrence in Stage I Lung Adenocarcinoma - PDF(Slides)

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This study aimed to identify clinicopathologic and genomic features associated with recurrence in stage I lung adenocarcinoma (LUAD) following surgery. The retrospective review included 511 patients with pathologic stage I LUAD who underwent R0 resection. All patients had next-generation sequencing performed. The median follow-up was 55.4 months.<br /><br />The five-year cumulative incidence of recurrence was 19%, with 63% of recurrences being distant. Lymphovascular invasion (LVI) and visceral pleural invasion (VPI) were independently associated with a higher risk of recurrence, while tumor size was not. The risk of distant recurrence was increased with LVI. MYC amplification/gain, which is consistent with previous findings in LUAD, was also identified as a predictor of poor outcomes.<br /><br />A prediction model for recurrence was constructed and assessed using a concordance index (C-index) of 0.77, demonstrating good prediction accuracy.<br /><br />The results suggest that tumor biology, indicated by aggressive clinicopathologic features and alterations in MYC, may outweigh tumor size in determining the risk of recurrence in stage I LUAD. These findings highlight the need for further studies to identify effective adjuvant therapies for the high-risk stage I population.<br /><br />Overall, this study provides valuable insights into the high-risk clinicopathologic and genomic features associated with recurrence in stage I LUAD, which may help guide treatment decisions and improve outcomes for patients with this disease.

Asset Subtitle

Cameron Fick

Meta Tag

Speaker Cameron Fick

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

clinicopathologic features

genomic features

recurrence

stage I lung adenocarcinoma

lymphovascular invasion

visceral pleural invasion

MYC amplification/gain

prediction model

tumor biology

adjuvant therapies