2023 World Conference on Lung Cancer (Posters)-EP07.04. Lymphatic Vascular Invasion: Diagnostic Variability and Overall Survival Impact on Patients Undergoing Surgical Resection of NSCLC

EP07.04. Lymphatic Vascular Invasion: Diagnostic Variability and Overall Survival Impact on Patients Undergoing Surgical Resection of NSCLC - PDF(Slides)

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This study focuses on lymphatic vascular invasion (LVI) in patients undergoing surgical resection for non-small cell lung cancer (NSCLC) and its impact on overall survival. The researchers used data from the National Cancer Database (NCDB) to identify patients who underwent lobectomy or sub-lobar resection and had lymph nodes examined. Propensity score matching (PSM) was used to analyze the impact of LVI on overall survival, adjusting for other factors.<br /><br />The study found that LVI status was reported in 91.5% of eligible patients, with 21.3% of them testing positive for LVI. LVI was independently associated with a significant decrease in overall survival. Academic medical centers, institutions with larger populations, and the mid-Atlantic region had higher rates of LVI tumors.<br /><br />The impact of LVI on overall survival was consistent across different node stages and tumor grades. Patients undergoing lobectomy with adequate lymph node dissection had a decreased overall survival if they had LVI-positive tumors. Similarly, for patients undergoing sub-lobar resection, LVI had an impact on overall survival when a sufficient number of lymph nodes were examined.<br /><br />The study highlights the variability in LVI rates based on hospital location/type and population. It suggests that LVI should be standardized and considered as a staging variable, and that it may be a determining factor for systemic therapy in certain patient groups.<br /><br />In conclusion, LVI in NSCLC patients undergoing surgical resection is associated with a decrease in overall survival. The study emphasizes the importance of considering LVI as a staging variable and incorporating it into treatment decisions for specific patient populations.

Asset Subtitle

Kemnasom Nwanwene

Meta Tag

Speaker Kemnasom Nwanwene

Topic Early-Stage NSCLC: Progress in Pathology

Keywords

lymphatic vascular invasion

LVI

non-small cell lung cancer

NSCLC

overall survival

lobectomy

sub-lobar resection

National Cancer Database

propensity score matching

staging variable