2023 World Conference on Lung Cancer (Posters)-EP07.05. Spontaneous Ventilation Video-assisted Thoracoscopic Surgery for Super-elderly NSCLC Patients: a Noninferiority Study.

EP07.05. Spontaneous Ventilation Video-assisted Thoracoscopic Surgery for Super-elderly NSCLC Patients: a Noninferiority Study. - PDF(Abstract)

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This study evaluated the feasibility and safety of spontaneous ventilation video-assisted thoracoscopic surgery (SV-VATS) in super-elderly patients with non-small cell lung cancer (NSCLC). A retrospective study was conducted on 324 NSCLC patients over the age of 80 who underwent either SV-VATS or mechanical ventilation (MV)-VATS. Propensity score matching was used to balance baseline characteristics between the two groups. Intraoperative and postoperative outcomes were compared, including surgery time, anesthesia time, post-anesthesia care unit (PACU) time, chest tube duration, the volume of chest drainage, bleeding, volume of urinary and liquid infusion, ventilation time, resuscitation time, postoperative length of stay, neutrophil-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), age-adjusted Charlson comorbidity index (ACCI), and complications in the PACU. Kaplan-Meier survival analysis and cox regression were conducted for overall survival (OS) and disease-free survival (DFS). <br /><br />After propensity score matching, 22 patients in the SV-VATS group and 44 patients in the MV-VATS group were included, with well-balanced baseline characteristics. The SV-VATS group had a shorter PACU time and resuscitation time compared to the MV-VATS group. There were no statistically significant differences in surgery time, anesthesia time, chest tube duration, volume of chest drainage, bleeding, urinary volume, volume of liquid infusion, ventilation time, postoperative length of stay, NLR, PLR, SII, and ACCI between the two groups. Complications in the PACU were similar. <br /><br />The median follow-up time was 23.8 months, and both OS and DFS were comparable between the SV-VATS and MV-VATS groups. The study concludes that SV-VATS may be a safe and feasible option for super-elderly NSCLC patients, but further large-scale prospective research is needed.

Asset Subtitle

Yulin Zhao

Meta Tag

Speaker Yulin Zhao

Topic Early-Stage NSCLC: Pushing the Boundaries

Keywords

spontaneous ventilation video-assisted thoracoscopic surgery

SV-VATS

super-elderly patients

non-small cell lung cancer

NSCLC

mechanical ventilation

MV-VATS

propensity score matching

intraoperative outcomes

postoperative outcomes