2023 World Conference on Lung Cancer (Posters)-EP08.02. A Prospective Study of Gallium-68 Ventilation and Perfusion PET/CT Before, During, and After Radiotherapy in Patients with NSCLC

EP08.02. A Prospective Study of Gallium-68 Ventilation and Perfusion PET/CT Before, During, and After Radiotherapy in Patients with NSCLC - PDF(Abstract)

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This study investigated the impact of radiotherapy on lung ventilation and perfusion in patients with non-small cell lung cancer (NSCLC). The researchers used Gallium-68 ventilation and perfusion PET/CT to assess changes in lung function before, during, and after radiotherapy. They also evaluated the relationship between lung function changes and clinical outcomes such as dyspnea and pneumonitis.<br /><br />A total of 67 patients with NSCLC were recruited for the study. The median age of the participants was 68, and 66% of them were male. All patients received definitive external beam radiotherapy, with a median dose of 60Gy. The researchers obtained baseline pulmonary function tests (PFTs) before treatment and collected data on PFTs, dyspnea, and pneumonitis at regular intervals up to 12 months after radiotherapy.<br /><br />The results showed that there were slight decreases in global lung ventilation and perfusion from baseline to 3 months post-treatment. Grade 2-3 pneumonitis occurred in 32% of patients, but this was not associated with changes in ventilation or perfusion. However, a relative reduction in forced expiratory volume in 1 second (FEV1) was associated with absolute changes in ventilation and perfusion.<br /><br />The researchers concluded that Gallium V/Q PET/CT can demonstrate changes in ventilated and perfused lung tissue after radiotherapy. These changes in lung function were associated with a reduction in FEV1 but were not predictive of clinical toxicity. The study provides valuable insights into the effects of radiotherapy on lung function in NSCLC patients and highlights the potential of Gallium PET/CT in assessing these changes.

Asset Subtitle

Neil Wallace

Meta Tag

Speaker Neil Wallace

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

radiotherapy

lung ventilation

lung perfusion

non-small cell lung cancer

NSCLC

Gallium-68 ventilation

Gallium-68 perfusion

PET/CT

dyspnea

pneumonitis