2023 World Conference on Lung Cancer (Posters)-EP08.02. Prognostic Role of Baseline PET/CT Parameters in Frail Patients with Inoperable Node-Positive Stage IIB-IIIC/Recurrent NSCLC

EP08.02. Prognostic Role of Baseline PET/CT Parameters in Frail Patients with Inoperable Node-Positive Stage IIB-IIIC/Recurrent NSCLC - PDF(Abstract)

Back to course

Pdf Summary

This study aims to investigate the prognostic role of baseline PET/CT parameters in frail patients with inoperable node-positive stage IIB-IIIC/recurrent non-small cell lung cancer (NSCLC) undergoing moderately hypofractionated radiotherapy. PET-based parameters, including metabolic tumor volume (MTV), standardized uptake value (SUV), and total lesion glycolysis (TLG), have been shown to be independent predictors in NSCLC patients. However, there is limited data on the prognostic value of these parameters in patients undergoing radiotherapy alone.<br /><br />The study included inoperable NSCLC patients with poor prognostic factors and severely compromised lung function. All patients received moderately hypofractionated image-guided radiotherapy (IGRT). Only patients who had previously undergone 18F-FDG PET/CT were included. The baseline PET parameters of the primary tumor and lymph node metastases were analyzed as possible prognostic markers for progression-free survival (PFS) and overall survival (OS).<br /><br />The study included 42 patients with a median age of 72 years. The median PFS and OS were 11.5 months and 24.3 months, respectively. The study found that a higher baseline MTV (>36.6 cc) was significantly associated with lower PFS and OS. A higher SUVmax (>12.04) was associated with worse PFS, and a higher TLG was associated with inferior PFS. On multivariate analysis, only MTV remained a significant prognosticator of OS.<br /><br />The findings suggest that baseline PET parameters can serve as prognosticators for PFS and OS in frail patients with inoperable NSCLC undergoing moderately hypofractionated radiotherapy. The study highlights the relevance of PET parameters in stratifying patient cohorts for future treatment algorithms. Further studies investigating the role of radiotherapy and immunotherapy in similar patient populations are warranted.

Asset Subtitle

Chukwuka Eze

Meta Tag

Speaker Chukwuka Eze

Topic Local-Regional NSCLC: Multimodality Therapy

Keywords

baseline PET/CT parameters

frail patients

inoperable node-positive stage IIB-IIIC/recurrent non-small cell lung cancer

moderately hypofractionated radiotherapy

metabolic tumor volume

standardized uptake value

total lesion glycolysis

prognostic markers

progression-free survival

overall survival