2023 World Conference on Lung Cancer (Posters)-EP08.03. Role of DCE MRI in Predicting Treatment Response to Induction Immunochemotherapy in Locally Advanced NSCLC Patients

EP08.03. Role of DCE MRI in Predicting Treatment Response to Induction Immunochemotherapy in Locally Advanced NSCLC Patients - PDF(Abstract)

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This study aimed to investigate the role of Dynamic Contrast Enhanced MRI (DCE-MRI) parameters in predicting tumor response to induction immuno-chemotherapy in locally advanced non-small cell lung cancer (LA-NSCLC) patients. A total of 112 LA-NSCLC patients treated with induction immuno-chemotherapy were included in the study. DCE-MRI was performed before and after treatment, and permeability parameters including endothelial transfer constant (Ktrans), reflux rate (Kep), fractional extravascular extracellular space volume (Ve), and fractional plasma volume (Vp) were calculated. The associations between these parameters and tumor response were evaluated. The performance of DCE-MRI parameters in predicting treatment response was examined using ROC curves. <br /><br />After two cycles of immuno-chemotherapy, 59.8% of patients achieved partial response (PR) and 40.2% achieved stable disease (SD). Patients with PR had significantly higher pre-treatment Ktrans and Ve compared to those with SD. The PR group also had significantly higher post-treatment Ktrans, Ve, and Vp compared to the SD group. However, there was no significant difference in the change (Δ) of these parameters between the two groups. <br /><br />The pre-treatment Ktrans showed favorable performance in predicting tumor response, with a sensitivity of 82.1% and specificity of 75.6%. The pre-treatment Ve and post-treatment Ktrans also showed moderate predictive performance. <br /><br />In conclusion, pre-treatment Ktrans from DCE-MRI can be a useful parameter in predicting early response to induction immuno-chemotherapy in LA-NSCLC patients. However, further validation through prospective studies is needed.

Asset Subtitle

DaQuan Wang

Meta Tag

Speaker DaQuan Wang

Topic Local-Regional NSCLC: Novel Therapies & Trials

Keywords

DCE-MRI

tumor response

induction immuno-chemotherapy

LA-NSCLC

permeability parameters

endothelial transfer constant

fractional extravascular extracellular space volume

fractional plasma volume

sensitivity

specificity