2023 World Conference on Lung Cancer (Posters)-EP08.04. Development of a Risk Score to Predict Postoperative Complications in Patients with Non-small Cell Lung Cancer

EP08.04. Development of a Risk Score to Predict Postoperative Complications in Patients with Non-small Cell Lung Cancer - PDF(Slides)

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The study aimed to identify potential risk factors associated with postoperative complications in patients with non-small cell lung cancer (NSCLC) and develop a risk score to predict these complications. The study included 300 NSCLC patients treated between 2017 and 2020, and complications were graded according to the Clavien-Dindo Classification.<br /><br />The primary endpoint was complications grade III and higher, while the secondary endpoint was postoperative in-hospital mortality. The study found that DLCO (diffusing capacity of the lung for carbon monoxide) was a strong risk factor for major complications, with lower DLCO levels significantly associated with a higher risk of major complications.<br /><br />A logistic regression model was developed to estimate the probability of major complications. Variables such as age, gender, DLCO, and method of surgery (minimally invasive or open) were weighted and assigned reference points to calculate the probability of complications. A 70-year-old female patient with DLCO at 80% of predicted, planned for minimally invasive lung resection, would have a total of 61 points, corresponding to a 15% probability of major complications. The logistic regression model had an accuracy of 73% to predict major complications.<br /><br />The study's strengths included a complete database and an easily applicable logistic regression model for clinical practice. However, there were limitations, such as the retrospective nature of the study, a limited number of enrolled patients, and heterogeneity in tumor stage.<br /><br />In conclusion, high DLCO and a minimally invasive approach were found to have the strongest impact on the absence of major postoperative complications. The developed risk score showed a reasonable accuracy in predicting major complications, but further prospective validation is needed for its application in surgical decision-making.

Asset Subtitle

Makhmudbek Mallaev

Meta Tag

Speaker Makhmudbek Mallaev

Topic Local-Regional NSCLC: Toxicities of Multimodality Therapy

Keywords

non-small cell lung cancer

postoperative complications

risk factors

risk score

Clavien-Dindo Classification

DLCO

diffusing capacity of the lung for carbon monoxide

logistic regression model

minimally invasive surgery

open surgery