2023 World Conference on Lung Cancer (Posters)-EP08.04. Evaluating Safety Profiles of Radiation-Related Toxicities in Thoracic Re-Irradiation

EP08.04. Evaluating Safety Profiles of Radiation-Related Toxicities in Thoracic Re-Irradiation - PDF(Slides)

Pdf Summary

This study analyzed 70 patients with thoracic malignancies who received re-irradiation between 2019 and 2022. Different radiation techniques were used, including 3D-CRT, SBRT, IMRT, and PSPT. The dosimetric parameters were evaluated from the first radiation treatment, re-irradiation, and composite plans. Radiation pneumonitis (RP), esophagitis, and tracheal toxicities were graded based on the CTCAE. The study aimed to understand the toxicity profile of patients who underwent thoracic re-irradiation and evaluate the dosimetric parameters. Results showed that out of the 18 patients with grade 3 RP, most of them developed it after their second RT course. About 19.7% of patients had a dose parameter of composite lung volume receiving 20Gy (V20) of 35%, but only half of them developed grade 3 RP. The majority of patients developed late RP beyond 1 year, emphasizing the need for careful management. One grade 5 toxicity was reported, which was a fatal pneumothorax after bronchoscopy. No statistical significance was found between the risk of RP and dose parameters. The study concluded that thoracic re-irradiation can be delivered safely without grade 5 toxicities. Late RP requires careful attention, and strict adherence to lung V20 of 35% is essential to reduce the risk. While no major airway or esophageal toxicities were observed, precautions should be taken to avoid high-grade toxicities to these organs in the re-irradiation setting. The study references previous research on re-irradiation for locoregionally recurrent lung cancer and emphasizes the importance of further research in this area.

Asset Subtitle

Rohan Patel

Meta Tag

Speaker Rohan Patel

Topic Local-Regional NSCLC: Toxicities of Multimodality Therapy

Keywords

re-irradiation

dosimetric parameters

radiation pneumonitis

thoracic malignancies

late RP

grade 5 toxicity

lung V20

high-grade toxicities

CTCAE

recurrent lung cancer