2023 World Conference on Lung Cancer (Posters)-EP09.01. Clinical Outcome of Palliative Thoracic Radiotherapy in Advanced Lung Cancer in the Modern Era - A Single Institution Experience

EP09.01. Clinical Outcome of Palliative Thoracic Radiotherapy in Advanced Lung Cancer in the Modern Era - A Single Institution Experience - PDF(Abstract)

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This study aimed to examine the treatment patterns and clinical outcomes of palliative thoracic radiation therapy (TRT) in advanced lung cancer patients at a single institution. The researchers retrospectively reviewed all patients with stage III to IV lung cancer who received palliative TRT from January 2018 to December 2019. They analyzed baseline demographics, treatment patterns, symptom control, survival, and toxicities. <br /><br />Overall, 154 patients were included in the study, with a median age of 76. Most patients had performance status 2 and stage IV disease, with 55% of stage IV patients having extra-thoracic metastases. Approximately 23% of patients had druggable driver mutations, and 16.8% received PD-1 or PD-L1 immunotherapy. The most common dose fractionations were 20Gy over 5 fractions (68%) and 30Gy over 10 fractions (25%). <br /><br />The main indications for palliative TRT were haemoptysis and pain. The symptom control rate at 3 months and 6 months after TRT was 85% and 78%, respectively. The median overall survival from the start of TRT was 5.0 months for the entire cohort and 3.4 months for patients with extra-thoracic metastases. Better performance status, stage, presence of driver mutations, use of systemic treatment, and a higher dose of TRT (30Gy) were associated with better survival. The overall toxicities were minimal, with grade 2 esophagitis being the most common. There were no grade 3 or above toxicities.<br /><br />The study concluded that most patients who received palliative TRT achieved good symptom control but had limited survival. The researchers suggested that better selection of dose fractionation based on stage and performance status may improve the quality of life and outcomes for this group of patients.

Asset Subtitle

Tsz Yeung Kam

Meta Tag

Speaker Tsz Yeung Kam

Topic Metastatic NSCLC: Local Therapies - Effects

Keywords

palliative thoracic radiation therapy

advanced lung cancer

treatment patterns

clinical outcomes

stage IV

extra-thoracic metastases

druggable driver mutations

symptom control rate

overall survival

toxicities