2023 World Conference on Lung Cancer (Posters)-EP09.01. Clinical Outcome of Palliative Thoracic Radiotherapy in Advanced Lung Cancer in the Modern Era - A Single Institution Experience

EP09.01. Clinical Outcome of Palliative Thoracic Radiotherapy in Advanced Lung Cancer in the Modern Era - A Single Institution Experience - PDF(Slides)

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This study aimed to review the treatment patterns and clinical outcomes of palliative thoracic radiotherapy (TRT) in advanced lung cancer patients in the modern era of targeted therapy and immunotherapy. The research analyzed data from 154 patients with stage III to IV lung cancer who received palliative TRT between January 2018 and December 2019. The treatment pattern of TRT, including dose fractionations, performance status, stage, presence of extra-thoracic metastases, use of systemic treatment, and presence of driver mutations, were analyzed. Symptom control assessments were evaluated at 3 and 6 months after TRT. Futile TRT, defined as death within 30 days from the start of TRT, was also recorded. Potential prognosticators of overall survival were analyzed using univariate and multivariate analysis.<br /><br />The study found that the majority of patients achieved good symptom control with TRT but had limited survival, even in the modern era of systemic treatment. Most patients received TRT at the end of their oncological journey for symptom palliation. A higher dose of 30Gy may benefit stage III patients or those with better performance status. The study also reported the incidence of toxicities associated with TRT, such as esophagitis and skin reactions.<br /><br />The limitations of the study include its retrospective analysis and relatively limited sample size. The findings highlight the importance of better selection of dose fractionation to improve the quality of life and outcomes for advanced lung cancer patients receiving palliative TRT. Overall, this research contributes to the understanding of the clinical outcomes of palliative TRT in the modern era and suggests that higher doses may be beneficial for certain patient populations.

Asset Subtitle

Tsz Yeung Kam

Meta Tag

Speaker Tsz Yeung Kam

Topic Metastatic NSCLC: Local Therapies - Effects

Keywords

palliative thoracic radiotherapy

advanced lung cancer

treatment patterns

clinical outcomes

targeted therapy

immunotherapy

dose fractionations

symptom control assessments

overall survival

higher doses