2023 World Conference on Lung Cancer (Posters)-EP09.01. Outcomes of Surgical Treatment for Stage IV Non-Small Cell Lung Cancer (NSCLC) in a Population-Based Cohort

EP09.01. Outcomes of Surgical Treatment for Stage IV Non-Small Cell Lung Cancer (NSCLC) in a Population-Based Cohort - PDF(Slides)

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A recent study evaluated the outcomes of surgical treatment for stage IV non-small cell lung cancer (NSCLC) in a population-based cohort. The study found that curative-intent resection was associated with better overall survival than expected for metastatic NSCLC, highlighting the importance of identifying patients with oligo-metastatic disease who could benefit from aggressive treatment. <br /><br />Metastatic NSCLC is typically considered incurable, with low survival rates. However, patients with oligo-metastatic disease may benefit from surgical resection aimed at curing the cancer. The study analyzed patients in a population-based cohort and compared their overall survival with that of patients who underwent resections for earlier stages of NSCLC.<br /><br />The study found that the five-year overall survival rate for stage I-III NSCLC was 61%, with a median overall survival of 8.3 years. In contrast, the five-year overall survival rate for stage IV NSCLC was 45%, with a median overall survival of 4 years. This indicates that surgical resection for stage IV NSCLC led to significantly better overall survival than expected.<br /><br />The study also looked at the site of metastatic disease and found that the five-year overall survival rates varied depending on the site. For example, the five-year overall survival rate was 29% for hepatic metastasis and 67% for soft tissue metastasis.<br /><br />The researchers call for prospective studies to standardize the selection of patients with oligo-metastatic disease and determine the optimal treatment approach for them. In conclusion, the study demonstrates the potential benefit of curative-intent surgical resection for select patients with stage IV NSCLC, underscoring the need for careful identification and appropriate treatment of patients with oligo-metastatic disease.

Asset Subtitle

Raymond Osarogiagbon

Meta Tag

Speaker Raymond Osarogiagbon

Topic Metastatic NSCLC: Local Therapies - Effects

Keywords

surgical treatment

stage IV non-small cell lung cancer

NSCLC

metastatic disease

curative-intent resection

overall survival

oligo-metastatic disease

aggressive treatment

prospective studies

optimal treatment approach