2023 World Conference on Lung Cancer (Posters)-EP10.01. Relationship between Impaired Fasting Glucose and Prognosis of the Disease in Patients with Advanced Stage Non-small Cell Lung Cancer.

EP10.01. Relationship between Impaired Fasting Glucose and Prognosis of the Disease in Patients with Advanced Stage Non-small Cell Lung Cancer. - PDF(Slides)

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This study aimed to investigate the relationship between impaired fasting glucose and the prognosis of patients with advanced stage non-small cell lung cancer (NSCLC). The researchers conducted a retrospective cohort study using data from 352 NSCLC patients at a hospital in Turkey. The patients were divided into three groups based on their fasting blood glucose levels: normoglycemic, pre-diabetic, and diabetic.<br /><br />The study found that overall survival and progression-free survival were not significantly different between the three groups. However, normoglycemic patients had a significantly higher survival time compared to pre-diabetic and diabetic patients. There was no significant difference in survival time between pre-diabetic and diabetic patients. The number of metastatic organs being more than one was found to increase mortality risk.<br /><br />Regarding treatment methods, chemotherapy and targeted therapy significantly increased survival time, while radiotherapy had no significant effect. In terms of progression-free survival, normoglycemic patients had a significantly higher survival time compared to pre-diabetic and diabetic patients. The number of organs with metastasis of more than two increased the risk of progression. Chemotherapy was not significantly effective on progression time, while targeted therapy significantly increased progression-free survival time.<br /><br />The study concluded that hyperglycemia shortens survival and progression-free survival in patients with advanced NSCLC, worsening the prognosis of the disease. It emphasized the importance of controlling blood glucose levels in lung cancer patients with impaired glucose intolerance and diabetes mellitus. The researchers recommended screening blood glucose levels during follow-up and treatment appointments and informing patients about the significance of maintaining proper blood glucose control.<br /><br />In summary, this study investigated the impact of impaired fasting glucose on the prognosis of patients with advanced NSCLC. It found that hyperglycemia had a negative effect on both overall survival and progression-free survival in these patients, highlighting the importance of managing blood glucose levels in lung cancer treatment.

Asset Subtitle

Berna Komurcuoglu

Meta Tag

Speaker Berna Komurcuoglu

Topic Metastatic NSCLC: Cytotoxic Therapy

Keywords

impaired fasting glucose

prognosis

NSCLC

retrospective cohort study

normoglycemic

diabetic

overall survival

progression-free survival

metastatic organs

hyperglycemia