2023 World Conference on Lung Cancer (Posters)-EP11.02. Nivolumab as Maintenance Therapy Following Platinum-Based Chemotherapy in EGFR-mutant Lung Cancer Patients After TKI Failure

EP11.02. Nivolumab as Maintenance Therapy Following Platinum-Based Chemotherapy in EGFR-mutant Lung Cancer Patients After TKI Failure - PDF(Abstract)

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Pdf Summary

This study investigated the efficacy of immunotherapy maintenance with nivolumab following platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) who had EGFR mutations and experienced EGFR-tyrosine kinase inhibitor (EGFR-TKI) failure. The study enrolled 26 patients who received platinum-based chemotherapy followed by nivolumab maintenance therapy. Patients received nivolumab every 2 weeks for 3 months, followed by every 4 weeks until disease progression or unacceptable toxicity occurred. The primary endpoint was progression-free survival (PFS), and secondary outcomes included overall survival (OS) and treatment-related adverse events (AEs). <br /><br />The results showed that the median PFS was 5.6 months and the median OS was 24.8 months. The disease control rate was 11.5% and the objective response rate was 7.7%. The tumor mutational burden was not related to treatment outcomes. Grade 3-4 treatment-related AEs occurred in 15.4% of patients, with increased alanine aminotransferase being the most frequent AE. <br /><br />In conclusion, nivolumab maintenance therapy following platinum-based chemotherapy did not provide clinical benefits in patients with EGFR-mutant NSCLC who had EGFR-TKI failure. This suggests that immunotherapy in this specific patient population may not be effective as a maintenance therapy.

Asset Subtitle

Jiwon Kim

Meta Tag

Speaker Jiwon Kim

Topic Metastatic NSCLC: Immunotherapy - Prospective

Keywords

immunotherapy

maintenance

nivolumab

platinum-based chemotherapy

metastatic non-small cell lung cancer

NSCLC

EGFR mutations

EGFR-tyrosine kinase inhibitor

progression-free survival

overall survival