2023 World Conference on Lung Cancer (Posters)-EP11.03. A Novel Approach for Personalized Strategy of Cancer Immunotherapy with Pattern Identification: From the Results of the HARMONY Study

EP11.03. A Novel Approach for Personalized Strategy of Cancer Immunotherapy with Pattern Identification: From the Results of the HARMONY Study - PDF(Abstract)

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The study presented at the WCLC 2023 conference aimed to investigate the differences in immune status and prognosis among patients with advanced non-small cell lung cancer (NSCLC) who receive immunotherapy. The researchers used a diagnostic method called pattern identification (PI), which evaluates the balance of the entire body system based on Yin and Yang principles in East Asia. <br /><br />The study included 170 patients scheduled for immunotherapy with pembrolizumab or atezolizumab as second-line or later treatment. Pattern identification was evaluated retrospectively based on questionnaires, pulse and tongue measurements at baseline. Blood samples were collected before and after the first cycle of treatment for immune profiling analysis. <br /><br />The patients were classified into two groups based on pattern identification: heat pattern and non-heat pattern. The median follow-up was 10.8 months. Patients with the heat pattern had longer overall survival (OS) compared to those with the non-heat pattern. In the pembrolizumab group, the heat pattern group showed a tendency of prolonged OS. Among patients with high PD-L1 expression, those with the heat pattern had significantly prolonged OS. However, there was no difference in progression-free survival between the two pattern groups. <br /><br />In terms of immune profiling, the study found that CD8 T cells expressing T cell factor 1, a phenotype associated with responsiveness to immunotherapy, significantly decreased in the non-heat pattern group. CD8 T cells expressing CD57, a marker associated with replicative senescence, significantly increased in the non-heat pattern group. Additionally, there was an increase in regulatory T cells expressing CTLA4 and a decrease in CD4 T cells in the non-heat pattern group during the first cycle of immunotherapy.<br /><br />The findings suggest that patients with the heat pattern in advanced NSCLC may have a better prognosis and immune response to immunotherapy. This study highlights the potential for personalized medicine based on pattern identification. Further research is needed to gain a better understanding of the role of pattern identification in cancer immunotherapy.

Asset Subtitle

Mi-kyung Jeong

Meta Tag

Speaker Mi-kyung Jeong

Topic Metastatic NSCLC: Immunotherapy - Retrospective

Keywords

WCLC 2023 conference

immune status

prognosis

advanced non-small cell lung cancer

NSCLC

immunotherapy

pattern identification

Yin and Yang principles

pembrolizumab

atezolizumab