2023 World Conference on Lung Cancer (Posters)-EP11.03. A Novel Approach for Personalized Strategy of Cancer Immunotherapy with Pattern Identification: From the Results of the HARMONY Study

EP11.03. A Novel Approach for Personalized Strategy of Cancer Immunotherapy with Pattern Identification: From the Results of the HARMONY Study - PDF(Slides)

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This study explores the use of personalized medicine in cancer immunotherapy using a traditional East Asian medicine diagnostic method called pattern identification (PI). The researchers conducted a multicenter observational study in South Korea involving patients with advanced non-small cell lung cancer (NSCLC) receiving immune checkpoint inhibitors (ICIs) pembrolizumab or atezolizumab. PI data was collected using a questionnaire, pulse diagnosis, and tongue diagnosis devices. The patients were classified into two groups based on the presence or absence of a heat pattern. The study aimed to investigate the differences in immune status and clinical outcomes between the two groups.<br /><br />The results showed that patients with the heat pattern had a better performance status compared to those without the heat pattern. In terms of survival outcomes, patients with the heat pattern had longer overall survival (OS) compared to those without the heat pattern, although the difference was not statistically significant. However, in the subgroup of patients with PD-L1 expression of 50% or higher, those with the heat pattern showed significantly prolonged OS. There were no differences in progression-free survival (PFS) between the two pattern groups.<br /><br />The study also analyzed immune profiles and found that the heat pattern group exhibited a more activated immune status compared to the non-heat pattern group. Specifically, the percentage of CD8 T cells expressing TCF-1, a phenotype associated with responsiveness to ICIs, significantly decreased in the non-heat pattern group.<br /><br />Overall, the study suggests that personalized medicine based on pattern identification may have potential benefits in cancer immunotherapy. Patients with the heat pattern showed better prognosis and immune response to ICIs. Further research is needed to better understand the mechanisms behind these findings and to explore the potential of pattern identification in cancer immunotherapy. The study was supported by the Korea Institute of Oriental Medicine.

Asset Subtitle

Mi-kyung Jeong

Meta Tag

Speaker Mi-kyung Jeong

Topic Metastatic NSCLC: Immunotherapy - Retrospective

Keywords

personalized medicine

cancer immunotherapy

East Asian medicine

pattern identification

multicenter observational study

non-small cell lung cancer

immune checkpoint inhibitors

heat pattern

immune status

clinical outcomes