2023 World Conference on Lung Cancer (Posters)-EP11.03. Site-Specific Response Patterns in Patients with Advanced NSCLC Treated with First-Line Systemic Therapy

EP11.03. Site-Specific Response Patterns in Patients with Advanced NSCLC Treated with First-Line Systemic Therapy - PDF(Slides)

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This study aimed to assess the influence of metastatic sites on the response patterns, progression, and survival of patients with advanced non-small cell lung cancer (NSCLC) receiving first-line systemic therapy. The study was conducted as a retrospective cohort study across two tertiary centers in Western Sydney.<br /><br />The results showed that liver metastases had a lower response rate to immune checkpoint inhibitors (ICIs) compared to lung and lymph node metastases. Patients with bone metastases had reduced overall response rate (ORR) and shorter overall survival (OS). Additionally, patients with bone metastases and high volume disease had reduced progression-free survival (PFS).<br /><br />The study also found that site-specific progressive disease was highest in the bone, liver, and brain, while site-specific partial response was highest in the lung, lymph nodes, and adrenal glands.<br /><br />The median PFS for the patients was 5 months, while the median OS was 17 months. The overall response rate was 41%.<br /><br />The findings suggest that site-specific response and resistance in NSCLC may be driven by unique mechanisms, highlighting the need for further translational research into the tumor microenvironment to understand the drivers of resistance.<br /><br />In conclusion, this study demonstrates that the site of metastases can influence the response patterns, progression, and survival outcomes in advanced NSCLC patients receiving first-line systemic therapy. Understanding the impact of site-specific factors can help guide treatment decisions and improve patient outcomes in this population.

Asset Subtitle

Lauren Brown

Meta Tag

Speaker Lauren Brown

Topic Metastatic NSCLC: Immunotherapy - Retrospective

Keywords

metastatic sites

response patterns

progression

survival

NSCLC

first-line therapy

retrospective study

liver metastases

bone metastases

tumor microenvironment