2023 World Conference on Lung Cancer (Posters)-EP12.01. A Case of Brain Metastases from Lung Cancer with Epilepsy and ECOG Score of 4 Successfully Treated with Aumolertinib

EP12.01. A Case of Brain Metastases from Lung Cancer with Epilepsy and ECOG Score of 4 Successfully Treated with Aumolertinib - PDF(Abstract)

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This case report discusses the successful treatment of a lung cancer patient with brain metastases, epilepsy, and poor physical condition using a targeted therapy called aumolertinib. Lung cancer patients with brain metastases have limited survival options, including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, treating patients with brain metastases and epilepsy is challenging. In this case, a 69-year-old male patient presented with a chief complaint of headache, blurred vision, nausea, and vomiting. He was diagnosed with lung cancer with brain metastases, pleural effusion, and a genetic mutation called EGFR 19Del. The patient received a treatment regimen that included aumolertinib for anti-tumor effects, medications to control intracranial pressure and improve cardiac function, epilepsy control, nutritional support therapy, and pleural effusion management. After three days of treatment, the patient regained consciousness and did not experience any further seizures. Two weeks later, brain imaging and chest scans showed a partial response to the treatment, and the patient's physical condition improved significantly. The patient achieved a progression-free survival of over 20 months with minimal adverse effects. This case report highlights the successful application of aumolertinib in a lung cancer patient with brain metastases, epilepsy, and poor physical condition. It suggests that aumolertinib has promising therapeutic potential in this patient population and warrants further investigation.

Asset Subtitle

Jing Quan Zhao

Meta Tag

Speaker Jing Quan Zhao

Topic Metastatic NSCLC: Targeted Therapy - EGFR/HER2

Keywords

lung cancer

brain metastases

epilepsy

poor physical condition

targeted therapy

aumolertinib

survival options

surgery

radiotherapy

chemotherapy